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Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19.
Li, Jinghong; Wei, Qi; Li, Willis X; McCowen, Karen C; Xiong, Wei; Liu, Jiao; Jiang, Wenlijun; Marin, Traci; Thomas, Robert L; He, Ming; Gongol, Brendan; Hepokoski, Mark; Yuan, Jason X-J; Shyy, John Y-J; Xiong, Nian; Malhotra, Atul.
  • Li J; From the Department of Medicine, University of California, San Diego, La Jolla, California.
  • Wei Q; the Department of Endocrinology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Li WX; From the Department of Medicine, University of California, San Diego, La Jolla, California.
  • McCowen KC; From the Department of Medicine, University of California, San Diego, La Jolla, California.
  • Xiong W; the Department of Endocrinology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Liu J; the Department of Endocrinology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Jiang W; the Department of Endocrinology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
  • Marin T; the Department of Health Sciences, Victor Valley College, Victorville, California.
  • Thomas RL; From the Department of Medicine, University of California, San Diego, La Jolla, California.
  • He M; From the Department of Medicine, University of California, San Diego, La Jolla, California.
  • Gongol B; From the Department of Medicine, University of California, San Diego, La Jolla, California.
  • Hepokoski M; From the Department of Medicine, University of California, San Diego, La Jolla, California.
  • Yuan JX; From the Department of Medicine, University of California, San Diego, La Jolla, California.
  • Shyy JY; From the Department of Medicine, University of California, San Diego, La Jolla, California. Electronic address: jshyy@health.ucsd.edu.
  • Xiong N; the Department of Endocrinology, Wuhan Red Cross Hospital, Wuhan, Hubei, China; the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.. Electronic address: nianxiong@hust.edu.cn.
  • Malhotra A; From the Department of Medicine, University of California, San Diego, La Jolla, California.
Endocr Pract ; 26(10): 1166-1172, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-1067866
ABSTRACT

OBJECTIVE:

Although type 2 diabetes mellitus (T2DM) has been reported as a risk factor for coronavirus disease 2019 (COVID-19), the effect of pharmacologic agents used to treat T2DM, such as metformin, on COVID-19 outcomes remains unclear. Metformin increases the expression of angiotensin converting enzyme 2, a known receptor for severe acute respiratory syndrome coronavirus 2. Data from people with T2DM hospitalized for COVID-19 were used to test the hypothesis that metformin use is associated with improved survival in this population.

METHODS:

Retrospective analyses were performed on de-identified clinical data from a major hospital in Wuhan, China, that included patients with T2DM hospitalized for COVID-19 during the recent epidemic. One hundred and thirty-one patients diagnosed with COVID-19 and T2DM were used in this study. The primary outcome was mortality. Demographic, clinical characteristics, laboratory data, diabetes medications, and respiratory therapy data were also included in the analysis.

RESULTS:

Of these 131 patients, 37 used metformin with or without other antidiabetes medications. Among the 37 metformin-taking patients, 35 (94.6%) survived and 2 (5.4%) did not survive. The mortality rates in the metformin-taking group versus the non-metformin group were 5.4% (2/37) versus 22.3% (21/94). Using multivariate analysis, metformin was found to be an independent predictor of survival in this cohort (P = .02).

CONCLUSION:

This study reveals a significant association between metformin use and survival in people with T2DM diagnosed with COVID-19. These clinical data are consistent with potential benefits of the use of metformin for COVID-19 patients with T2DM.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / COVID-19 / Metformin Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Endocr Pract Journal subject: Endocrinology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / COVID-19 / Metformin Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Endocr Pract Journal subject: Endocrinology Year: 2020 Document Type: Article