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Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19.
Augusto, João B; Menacho, Katia; Andiapen, Mervyn; Bowles, Ruth; Burton, Maudrian; Welch, Sophie; Bhuva, Anish N; Seraphim, Andreas; Pade, Corinna; Joy, George; Jensen, Melanie; Davies, Rhodri H; Captur, Gabriella; Fontana, Marianna; Montgomery, Hugh; O'Brien, Ben; Hingorani, Aroon D; Cutino-Moguel, Teresa; McKnight, Áine; Abbass, Hakam; Alfarih, Mashael; Alldis, Zoe; Baca, Georgina L; Boulter, Alex; Bracken, Olivia V; Bullock, Natalie; Champion, Nicola; Chan, Carmen; Couto-Parada, Xose; Dieobi-Anene, Keenan; Feehan, Karen; Figtree, Gemma; Figtree, Melanie C; Finlay, Malcolm; Forooghi, Nasim; Gibbons, Joseph M; Griffiths, Peter; Hamblin, Matt; Howes, Lee; Itua, Ivie; Jones, Meleri; Jardim, Victor; Kapil, Vikas; Jason Lee, Wing-Yiu; Mandadapu, Vineela; Mfuko, Celina; Mitchelmore, Oliver; Palma, Susana; Patel, Kush; Petersen, Steffen E.
  • Augusto JB; Institute of Cardiovascular Science, University College London, London, UK.
  • Menacho K; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Andiapen M; Institute of Cardiovascular Science, University College London, London, UK.
  • Bowles R; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Burton M; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Welch S; Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
  • Bhuva AN; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Seraphim A; Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
  • Pade C; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Joy G; William Harvey Research Institute, Queen Mary University of London, London, UK.
  • Jensen M; NIHR Cardiovascular Biomedical Research Unit, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Davies RH; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Captur G; Institute of Cardiovascular Science, University College London, London, UK.
  • Fontana M; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Montgomery H; Institute of Cardiovascular Science, University College London, London, UK.
  • O'Brien B; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Hingorani AD; William Harvey Research Institute, Queen Mary University of London, London, UK.
  • Cutino-Moguel T; The Blizard Institute, Queen Mary University of London School of Medicine and Dentistry, London, UK.
  • McKnight Á; Institute of Cardiovascular Science, University College London, London, UK.
  • Abbass H; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Alfarih M; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Alldis Z; Institute of Cardiovascular Science, University College London, London, UK.
  • Baca GL; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Boulter A; Institute of Cardiovascular Science, University College London, London, UK.
  • Bracken OV; Royal Free London NHS Foundation Trust, London, UK.
  • Bullock N; MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
  • Champion N; Institute of Cardiovascular Science, University College London, London, UK.
  • Chan C; Royal Free London NHS Foundation Trust, London, UK.
  • Couto-Parada X; Centre for Human Health and Performance, University College London, London, UK.
  • Dieobi-Anene K; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Feehan K; William Harvey Research Institute, Queen Mary University of London, London, UK.
  • Figtree G; Institute of Cardiovascular Science, University College London, London, UK.
  • Figtree MC; Department of Virology, Barts Health NHS Trust, London, UK.
  • Finlay M; The Blizard Institute, Queen Mary University of London School of Medicine and Dentistry, London, UK.
  • Forooghi N; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Gibbons JM; Institute of Cardiovascular Science, University College London, London, UK.
  • Griffiths P; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Hamblin M; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Howes L; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Itua I; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Jones M; Division of Medicine, University College London, London, UK.
  • Jardim V; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Kapil V; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Jason Lee WY; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Mandadapu V; Department of Virology, Barts Health NHS Trust, London, UK.
  • Mfuko C; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
  • Mitchelmore O; Division of Medicine, University College London, London, UK.
  • Palma S; Royal North Shore Hospital; The University of Sydney, Sydney, Australia.
  • Patel K; Royal North Shore Hospital; The University of Sydney, Sydney, Australia.
  • Petersen SE; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK, London, UK.
Wellcome Open Res ; 5: 179, 2020.
Article in English | MEDLINE | ID: covidwho-1068028
Semantic information from SemMedBD (by NLM)
1. Protection COEXISTS_WITH COVID-19
Subject
Protection
Predicate
COEXISTS_WITH
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. intensive care unit LOCATION_OF Work
Subject
intensive care unit
Predicate
LOCATION_OF
Object
Work
4. Immune response PROCESS_OF Health Personnel
Subject
Immune response
Predicate
PROCESS_OF
Object
Health Personnel
5. Protection COEXISTS_WITH COVID-19
Subject
Protection
Predicate
COEXISTS_WITH
Object
COVID-19
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. intensive care unit LOCATION_OF Work
Subject
intensive care unit
Predicate
LOCATION_OF
Object
Work
8. Immune response PROCESS_OF Health Personnel
Subject
Immune response
Predicate
PROCESS_OF
Object
Health Personnel
ABSTRACT

Background:

Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, with less focus on the asymptomatic or paucisymptomatic. We established a bioresource with serial sampling of health care workers (HCWs) designed to obtain samples before and during mainly mild disease, with follow-up sampling to evaluate the quality and duration of immune memory.

Methods:

We conducted a prospective study on HCWs from three hospital sites in London, initially at a single centre (recruited just prior to first peak community transmission in London), but then extended to multiple sites 3 weeks later (recruitment still ongoing, target n=1,000). Asymptomatic participants attending work complete a health questionnaire, and provide a nasal swab (for SARS-CoV-2 RNA by RT-PCR tests) and blood samples (mononuclear cells, serum, plasma, RNA and DNA are biobanked) at 16 weekly study visits, and at 6 and 12 months.

Results:

Preliminary baseline results for the first 731 HCWs (400 single-centre, 331 multicentre extension) are presented. Mean age was 38±11 years; 67% are female, 31% nurses, 20% doctors, and 19% work in intensive care units. COVID-19-associated risk factors were 37% black, Asian or minority ethnicities; 18% smokers; 13% obesity; 11% asthma; 7% hypertension and 2% diabetes mellitus. At baseline, 41% reported symptoms in the preceding 2 weeks. Preliminary test results from the initial cohort (n=400) are available PCR at baseline for SARS-CoV-2 was positive in 28 of 396 (7.1%, 95% CI 4.9-10.0%) and 15 of 385 (3.9%, 2.4-6.3%) had circulating IgG antibodies.

Conclusions:

This COVID-19 bioresource established just before the peak of infections in the UK will provide longitudinal assessments of incident infection and immune responses in HCWs through the natural time course of disease and convalescence. The samples and data from this bioresource are available to academic collaborators by application  https//covid-consortium.com/application-for-samples/.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Risk factors Language: English Journal: Wellcome Open Res Year: 2020 Document Type: Article Affiliation country: Wellcomeopenres.16051.2

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Risk factors Language: English Journal: Wellcome Open Res Year: 2020 Document Type: Article Affiliation country: Wellcomeopenres.16051.2