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[Covid-19 and clinical-epidemiological research in Italy: proposal of a research agenda on priority topics by the Italian association of epidemiology]. / Covid-19 e ricerca clinico-epidemiologica in Italia: proposta di un'agenda di ricerca su temi prioritari da parte dell'Associazione italiana di epidemiologia.
Ciccone, Giovannino; Deandrea, Silvia; Clavenna, Antonio; Kirchmayer, Ursula; Simeon, Vittorio; Acampora, Anna; Agabiti, Nerina; Angelici, Laura; Banzi, Roita; Cadum, Ennio; Castiglione, Anna; Chiodini, Paolo; Colombo, Cinzia; Ferroni, Eliana; Migliore, Enrica; Nisticò, Lorenza; Pagano, Eva; Sabelli, Anna Maria; Sacerdote, Carlotta; Silvestri, Caterina; Soldati, Salvatore; Stranges, Saverio; Tirani, Marcello; Davoli, Marina; Galassi, Claudia; Forastiere, Francesco.
  • Ciccone G; SSD epidemiologia clinica e valutativa, AOU Città della salute e della scienza di Torino, CPO Piemonte, Torino; gianni.ciccone@cpo.it.
  • Deandrea S; Dipartimento di igiene e prevenzione sanitaria, ATS di Pavia.
  • Clavenna A; Istituto di ricerche farmacologiche Mario Negri IRCCS, Milano.
  • Kirchmayer U; Dipartimento epidemiologia del Servizio sanitario regionale del Lazio, ASL Roma 1, Roma.
  • Simeon V; Unità di statistica medica, Università degli Studi della Campania "Luigi Vanvitelli", Napoli.
  • Acampora A; Dipartimento epidemiologia del Servizio sanitario regionale del Lazio, ASL Roma 1, Roma.
  • Agabiti N; Dipartimento epidemiologia del Servizio sanitario regionale del Lazio, ASL Roma 1, Roma.
  • Angelici L; Dipartimento epidemiologia del Servizio sanitario regionale del Lazio, ASL Roma 1, Roma.
  • Banzi R; Istituto di ricerche farmacologiche Mario Negri IRCCS, Milano.
  • Cadum E; Dipartimento di igiene e prevenzione sanitaria, ATS di Pavia.
  • Castiglione A; SSD epidemiologia clinica e valutativa, AOU Città della salute e della scienza di Torino, CPO Piemonte, Torino.
  • Chiodini P; SSD epidemiologia clinica e valutativa, AOU Città della salute e della scienza di Torino, CPO Piemonte, Torino.
  • Colombo C; Istituto di ricerche farmacologiche Mario Negri IRCCS, Milano.
  • Ferroni E; UOC Servizio epidemiologico regionale e registri, Azienda Zero, Regione del Veneto, Padova.
  • Migliore E; SSD epidemiologia clinica e valutativa, AOU Città della salute e della scienza di Torino, CPO Piemonte, Torino.
  • Nisticò L; Centro di riferimento per le scienze comportamentali e la salute mentale, Istituto superiore di sanità, Roma.
  • Pagano E; SSD epidemiologia clinica e valutativa, AOU Città della salute e della scienza di Torino, CPO Piemonte, Torino.
  • Sabelli AM; Medico ospedaliero in pensione, Milano.
  • Sacerdote C; SC epidemiologia dei tumori, AOU Città della salute e della scienza di Torino, CPO Piemonte, Torino.
  • Silvestri C; Osservatorio di epidemiologia, Agenzia regionale di sanità della Toscana, Firenze.
  • Soldati S; Dipartimento epidemiologia del Servizio sanitario regionale del Lazio, ASL Roma 1, Roma.
  • Stranges S; Department of epidemiology and biostatistics, Schulich School of Medicine & Dentistry, Western University, in London, Ontario (Canada).
  • Tirani M; Dipartimento di igiene e prevenzione sanitaria, ATS di Pavia.
  • Davoli M; Dipartimento epidemiologia del Servizio sanitario regionale del Lazio, ASL Roma 1, Roma.
  • Galassi C; SSD epidemiologia clinica e valutativa, AOU Città della salute e della scienza di Torino, CPO Piemonte, Torino.
  • Forastiere F; Istituto per la ricerca e l'innovazione biomedica, Consiglio nazionale delle ricerche, Palermo.
Epidemiol Prev ; 44(5-6 Suppl 2): 51-59, 2020.
Article in Italian | MEDLINE | ID: covidwho-1068124
Semantic information from SemMedBD (by NLM)
1. COVID-19 AFFECTS Italians
Subject
COVID-19
Predicate
AFFECTS
Object
Italians
2. COVID-19 AFFECTS Italians
Subject
COVID-19
Predicate
AFFECTS
Object
Italians
ABSTRACT

BACKGROUND:

the Covid-19 pandemic has provoked a huge of clinical and epidemiological research initiatives, especially in the most involved countries. However, this very large effort was characterized by several methodological weaknesses, both in the field of discovering effective treatments (with too many small and uncontrolled trials) and in the field of identifying preventable risks and prognostic factors (with too few large, representative and well-designed cohorts or case-control studies).

OBJECTIVES:

in response to the fragmented and uncoordinated research production on Covid-19, the   italian Association of Epidemiology (AIE) stimulated the formation of a working group (WG) with the aims of identifying the most important gaps in knowledge and to propose a structured research agenda of clinical and epidemiological studies considered at high priority on Covid-19, including recommendations on the preferable methodology.

METHODS:

the WG was composed by 25 subjects, mainly epidemiologists, statisticians, and other experts in specific fields, who have voluntarily agreed to the proposal. The agreement on a list of main research questions and on the structure of the specific documents to be produced were defined through few meetings and cycles of document exchanges.

RESULTS:

twelve main research questions on Covid-19 were identified, covering aetiology, prognosis, interventions, follow-up and impact on general and specific populations (children, pregnant women). For each of them, a two-page form was developed, structured in background, main topics, methods (with recommendations on preferred study design and warnings for bias prevention) and an essential bibliography.

CONCLUSIONS:

this research agenda represents an initial contribution to direct clinical and epidemiological research efforts on high priority topics with a focus on methodological aspects. Further development and refinements of this agenda by Public Health Authorities are encouraged.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Research / Epidemiologic Research Design / Pandemics / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Clinical Practice Guide / Observational study / Prognostic study / Risk factors / Screening study Limits: Adult / Aged / Child / Female / Humans / Male / Middle aged / Pregnancy Country/Region as subject: Europa Language: Italian Journal: Epidemiol Prev Journal subject: Epidemiology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Research / Epidemiologic Research Design / Pandemics / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Clinical Practice Guide / Observational study / Prognostic study / Risk factors / Screening study Limits: Adult / Aged / Child / Female / Humans / Male / Middle aged / Pregnancy Country/Region as subject: Europa Language: Italian Journal: Epidemiol Prev Journal subject: Epidemiology Year: 2020 Document Type: Article