[Covid-19 and clinical-epidemiological research in Italy: proposal of a research agenda on priority topics by the Italian association of epidemiology]. / Covid-19 e ricerca clinico-epidemiologica in Italia: proposta di un'agenda di ricerca su temi prioritari da parte dell'Associazione italiana di epidemiologia.
Epidemiol Prev
; 44(5-6 Suppl 2): 51-59, 2020.
Article
in Italian
| MEDLINE | ID: covidwho-1068124
ABSTRACT
BACKGROUND:
the Covid-19 pandemic has provoked a huge of clinical and epidemiological research initiatives, especially in the most involved countries. However, this very large effort was characterized by several methodological weaknesses, both in the field of discovering effective treatments (with too many small and uncontrolled trials) and in the field of identifying preventable risks and prognostic factors (with too few large, representative and well-designed cohorts or case-control studies).OBJECTIVES:
in response to the fragmented and uncoordinated research production on Covid-19, the italian Association of Epidemiology (AIE) stimulated the formation of a working group (WG) with the aims of identifying the most important gaps in knowledge and to propose a structured research agenda of clinical and epidemiological studies considered at high priority on Covid-19, including recommendations on the preferable methodology.METHODS:
the WG was composed by 25 subjects, mainly epidemiologists, statisticians, and other experts in specific fields, who have voluntarily agreed to the proposal. The agreement on a list of main research questions and on the structure of the specific documents to be produced were defined through few meetings and cycles of document exchanges.RESULTS:
twelve main research questions on Covid-19 were identified, covering aetiology, prognosis, interventions, follow-up and impact on general and specific populations (children, pregnant women). For each of them, a two-page form was developed, structured in background, main topics, methods (with recommendations on preferred study design and warnings for bias prevention) and an essential bibliography.CONCLUSIONS:
this research agenda represents an initial contribution to direct clinical and epidemiological research efforts on high priority topics with a focus on methodological aspects. Further development and refinements of this agenda by Public Health Authorities are encouraged.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Research
/
Epidemiologic Research Design
/
Pandemics
/
SARS-CoV-2
/
COVID-19
Type of study:
Cohort study
/
Etiology study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
/
Pregnancy
Country/Region as subject:
Europa
Language:
Italian
Journal:
Epidemiol Prev
Journal subject:
Epidemiology
Year:
2020
Document Type:
Article
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