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Treatment guidelines for COVID-19 infected patients
Medicina Interna de Mexico ; 34(4):509-529, 2021.
Article in Spanish | Scopus | ID: covidwho-1068234
ABSTRACT

BACKGROUND:

New information for potential treatments against SARS-CoV-2 is rapidly increasing. As a result, countries and organizations have begun to release therapeutic guidelines.

OBJECTIVE:

To provide a synopsis of the recommendations supported in evidence-based guidelines for therapeutic options with potential activity against SARS-CoV-2.

METHOD:

Rapid systematic review of guidelines and/or protocols that provide interim clinical guidance for COVID-19 disease were extracted from PubMed/Medline, Web of Science, Scopus, Scielo, Google Scholar, and a general Google search. Duplicates were removed and a summary of the proposed interventions was included. A benefit risk analysis was then conducted.

RESULTS:

Twenty guidelines and/or protocols were selected;the majority of which came from Europe and Latin America. Seventeen interventions were identified and classified into 6 pharmacological groups. Antimalarials, lopinavir/ritonavir and remdesivir were the only agents recommended and supported by clinical trials. The remaining interventions were recommended based on indirect evidence, observational studies, or in vitro studies.

CONCLUSIONS:

Antimalarials have shown results against COVID-19 with surrogate outcomes and the presence of serious adverse events. We recommend active monitoring of agents with potential efficacy against SARS-CoV-2 and incorporating the results in national guidelines and protocols. Clinical trials should be conducted to show direct benefit with clinically relevant outcomes in various populations. © 2020 Comunicaciones Cientificas Mexicanas S.A. de C.V.. All rights reserved.

Full text: Available Collection: Databases of international organizations Database: Scopus Language: Spanish Journal: Medicina Interna de Mexico Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Scopus Language: Spanish Journal: Medicina Interna de Mexico Year: 2021 Document Type: Article