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COVID-19 as an independent risk factor for subclinical placental dysfunction.
Jaiswal, Nishtha; Puri, Manju; Agarwal, Kiran; Singh, Smita; Yadav, Reena; Tiwary, Narendra; Tayal, Prerna; Vats, Barkha.
  • Jaiswal N; Department of Obstetrics and Gynecology, Smt Sucheta Kriplani Hospital and Lady Hardinge Medical College, New Delhi, India. Electronic address: nishtha.amu@gmail.com.
  • Puri M; Department of Obstetrics and Gynecology, Smt Sucheta Kriplani Hospital and Lady Hardinge Medical College, New Delhi, India.
  • Agarwal K; Department of Pathology, Lady Hardinge Medical College, New Delhi, India.
  • Singh S; Department of Pathology, Lady Hardinge Medical College, New Delhi, India.
  • Yadav R; Department of Obstetrics and Gynecology, Smt Sucheta Kriplani Hospital and Lady Hardinge Medical College, New Delhi, India.
  • Tiwary N; Department of Biostatistics, RG Kar Medical College, Kolkata, India.
  • Tayal P; Department of Obstetrics and Gynecology, Smt Sucheta Kriplani Hospital and Lady Hardinge Medical College, New Delhi, India.
  • Vats B; Department of Obstetrics and Gynecology, Smt Sucheta Kriplani Hospital and Lady Hardinge Medical College, New Delhi, India.
Eur J Obstet Gynecol Reprod Biol ; 259: 7-11, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1068900
ABSTRACT

BACKGROUND:

The pandemic of the severe acute respiratory distress syndrome-associated Coronavirus-2 (SARS-CoV-2) has affected millions around the world. In pregnancy the dangers to the mother and fetus are still being explored. SARS-CoV2 can potentially compromise maternal and neonatal outcomes and this may be dependent on the pregnancy stage during which the infection occurs.

OBJECTIVE:

The present study was done to find the histopathological alterations in the placenta of SARS-CoV-2 positive pregnancies with either no symptoms or mild coronavirus disease (COVID)-19 related symptoms and its association with neonatal outcomes. STUDY

DESIGN:

This was a prospective analytical study. Twenty seven asymptomatic or mildly symptomatic SARS-CoV-2 positive pregnant women with a singleton pregnancy delivered between 1st July 2020 and 15th September 2020, were included as cases. An equal number of SARS-CoV-2 negative singleton pregnancies matched for maternal and gestational age during the same period were included as controls. After delivery the histopathological examination of the placenta of these women was done and the findings recorded on a predesigned proforma based on the Amsterdam consensus criteria for evidence of maternal and fetal vascular malperfusion changes.

RESULTS:

The baseline characteristics were comparable between the cases and controls. The following features of maternal vascular malperfusion (MVM) were significantly higher in the placentae of COVID-19 positive pregnancies retroplacental hematomas (RPH), accelerated villous maturation (AVM), distal villous hyperplasia (DVH), atherosis, fibrinoid necrosis, mural hypertrophy of membrane arterioles (MHMA), vessel ectasia and persistence of intramural endovascular trophoblast (PIEVT). Fetal vascular malperfusion (FVM) significantly associated with the positive pregnancies were chorioangiosis, thrombosis of the fetal chorionic plate (TFCP), intramural fibrin deposition (IMFD) and vascular ectasia. Additionally, perivillous fibrin deposition was also significantly higher in the placentae of cases. The percentage of spontaneously delivered women was comparable in the two groups. The sex and weight of the newborn and the number of live births were comparable between the two groups.

CONCLUSIONS:

Asymptomatic or mildly symptomatic SARS-CoV-2 positive pregnant women, with otherwise uncomplicated pregnancies, show evidence of placental injury at a microscopic level. Similar findings have been demonstrated in other studies too. This placental injury apparently does not lead to poor pregnancy outcomes. The extent of this injury in symptomatic cases of COVID-19 pregnancies and its consequences on the outcomes need to be analysed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Placenta / Placenta Diseases / Pregnancy Complications, Infectious / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy / Young adult Language: English Journal: Eur J Obstet Gynecol Reprod Biol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Placenta / Placenta Diseases / Pregnancy Complications, Infectious / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy / Young adult Language: English Journal: Eur J Obstet Gynecol Reprod Biol Year: 2021 Document Type: Article