Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples.
Gut Microbes
; 13(1): 1-9, 2021.
Article
in English
| MEDLINE | ID: covidwho-1069185
ABSTRACT
Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not change the entry or replication of SARS-CoV-2 in intestinal cells. These metabolites had no effect on intestinal cells' permeability and presented only minor effects on the production of anti-viral and inflammatory mediators. Together our findings indicate that the changes in microbiota composition of patients with COVID-19 and, particularly, of SCFAs do not interfere with the SARS-CoV-2 infection in the intestine.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Fatty Acids, Volatile
/
Gastrointestinal Microbiome
/
COVID-19
/
Intestinal Mucosa
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
Gut Microbes
Year:
2021
Document Type:
Article
Affiliation country:
19490976.2021.1874740
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