Your browser doesn't support javascript.
Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19-United States, March-September 2020.
Pennington, Audrey F; Kompaniyets, Lyudmyla; Summers, April D; Danielson, Melissa L; Goodman, Alyson B; Chevinsky, Jennifer R; Preston, Leigh Ellyn; Schieber, Lyna Z; Namulanda, Gonza; Courtney, Joseph; Strosnider, Heather M; Boehmer, Tegan K; Mac Kenzie, William R; Baggs, James; Gundlapalli, Adi V.
  • Pennington AF; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Kompaniyets L; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Summers AD; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Danielson ML; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Goodman AB; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Chevinsky JR; Commissioned Corps, United States Public Health Service, Rockville, Maryland, USA.
  • Preston LE; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Schieber LZ; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Namulanda G; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Courtney J; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Strosnider HM; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Boehmer TK; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Mac Kenzie WR; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Baggs J; Commissioned Corps, United States Public Health Service, Rockville, Maryland, USA.
  • Gundlapalli AV; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Open Forum Infect Dis ; 8(2): ofaa638, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1069293
Semantic information from SemMedBD (by NLM)
1. Patient in hospital PROCESS_OF Adult
Subject
Patient in hospital
Predicate
PROCESS_OF
Object
Adult
2. COVID-19 PROCESS_OF Adult
Subject
COVID-19
Predicate
PROCESS_OF
Object
Adult
3. Invasive mechanical ventilation NOS ADMINISTERED_TO Patients
Subject
Invasive mechanical ventilation NOS
Predicate
ADMINISTERED_TO
Object
Patients
4. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Patients
5. Patient in hospital PROCESS_OF Persons
Subject
Patient in hospital
Predicate
PROCESS_OF
Object
Persons
6. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
7. Patient in hospital PROCESS_OF Adult
Subject
Patient in hospital
Predicate
PROCESS_OF
Object
Adult
8. COVID-19 PROCESS_OF Adult
Subject
COVID-19
Predicate
PROCESS_OF
Object
Adult
9. Invasive mechanical ventilation NOS ADMINISTERED_TO Patients
Subject
Invasive mechanical ventilation NOS
Predicate
ADMINISTERED_TO
Object
Patients
10. Cessation of life PROCESS_OF Patients
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Patients
11. Patient in hospital PROCESS_OF Persons
Subject
Patient in hospital
Predicate
PROCESS_OF
Object
Persons
12. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
ABSTRACT

BACKGROUND:

Older adults and people from certain racial and ethnic groups are disproportionately represented in coronavirus disease 2019 (COVID-19) hospitalizations and deaths.

METHODS:

Using data from the Premier Healthcare Database on 181 813 hospitalized adults diagnosed with COVID-19 during March-September 2020, we applied multivariable log-binomial regression to assess the associations between age and race/ethnicity and COVID-19 clinical severity (intensive care unit [ICU] admission, invasive mechanical ventilation [IMV], and death) and to determine whether the impact of age on clinical severity differs by race/ethnicity.

RESULTS:

Overall, 84 497 (47%) patients were admitted to the ICU, 29 078 (16%) received IMV, and 27 864 (15%) died in the hospital. Increased age was strongly associated with clinical severity when controlling for underlying medical conditions and other covariates; the strength of this association differed by race/ethnicity. Compared with non-Hispanic White patients, risk of death was lower among non-Hispanic Black patients (adjusted risk ratio, 0.96; 95% CI, 0.92-0.99) and higher among Hispanic/Latino patients (risk ratio [RR], 1.15; 95% CI, 1.09-1.20), non-Hispanic Asian patients (RR, 1.16; 95% CI, 1.09-1.23), and patients of other racial and ethnic groups (RR, 1.13; 95% CI, 1.06-1.21). Risk of ICU admission and risk of IMV were elevated among some racial and ethnic groups.

CONCLUSIONS:

These results indicate that age is a driver of poor outcomes among hospitalized persons with COVID-19. Additionally, clinical severity may be elevated among patients of some racial and ethnic minority groups. Public health strategies to reduce severe acute respiratory syndrome coronavirus 2 infection rates among older adults and racial and ethnic minorities are essential to reduce poor outcomes.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Randomized controlled trials / Risk factors Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Randomized controlled trials / Risk factors Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid