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Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases.
Dolby, Heather W; Potey, Philippe; Wilder-Smith, Annika B; Clohisey, Sara; Millar, Jonathan E; Baillie, J Kenneth; Dorward, David A; Lucas, Christopher D; Russell, Clark D.
  • Dolby HW; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
  • Potey P; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
  • Wilder-Smith AB; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
  • Clohisey S; Roslin Institute, Division of Genetics and Genomics, University of Edinburgh, Edinburgh, United Kingdom.
  • Millar JE; Roslin Institute, Division of Genetics and Genomics, University of Edinburgh, Edinburgh, United Kingdom.
  • Baillie JK; Roslin Institute, Division of Genetics and Genomics, University of Edinburgh, Edinburgh, United Kingdom.
  • Dorward DA; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
  • Lucas CD; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
  • Russell CD; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom.
Open Forum Infect Dis ; 8(2): ofaa640, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1069294
ABSTRACT
Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n  =  455 patients), severe acute respiratory syndrome ([SARS] n  =  37), Middle East respiratory syndrome (n  =  2), adenovirus (n  =  34), and respiratory syncytial virus (n  =  30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid