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Childhood multisystem inflammatory syndrome associated with COVID-19 (MIS-C): a diagnostic and treatment guidance from the Rheumatology Study Group of the Italian Society of Pediatrics.
Cattalini, Marco; Taddio, Andrea; Bracaglia, Claudia; Cimaz, Rolando; Paolera, Sara Della; Filocamo, Giovanni; La Torre, Francesco; Lattanzi, Bianca; Marchesi, Alessandra; Simonini, Gabriele; Zuccotti, Gianvincenzo; Zunica, Fiammetta; Villani, Alberto; Ravelli, Angelo.
  • Cattalini M; Pediatrics Clinic, University of Brescia and ASST Spedali Civili di Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy. marco.cattalini@unibs.it.
  • Taddio A; University of Brescia, P.zza Del Mercato 15, Brescia, Italy. marco.cattalini@unibs.it.
  • Bracaglia C; Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137, Trieste, Italy.
  • Cimaz R; University of Trieste, Piazzale Europa 2, 34100, Trieste, Italy.
  • Paolera SD; Division of Rheumatology, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio, 4, 00165, Rome, Italy.
  • Filocamo G; Department of Clinical Sciences and Community Health, University of Milan, Via Commenda 19, 20122, Milan, Italy.
  • La Torre F; University of Trieste, Piazzale Europa 2, 34100, Trieste, Italy.
  • Lattanzi B; Pediatric Intermediate Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda 9, 20122, Milan, Italy.
  • Marchesi A; Pediatric Rheumatology Center, Pediatric Unit, "Giovanni XXIII", Pediatric Hospital, Via Giovanni Amendola 207, 70126, Bari, Italy.
  • Simonini G; SOD Pediatria, Ospedali Riuniti, Via Conca 71, Torrette, 60126, Ancona, Italy.
  • Zuccotti G; Bambino Gesu' Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165, Rome, Italy.
  • Zunica F; Pediatric Rheumatology Unit, AOU Meyer, University of Florence, Via Gaetano Pieraccini 24, 50139, Florence, Italy.
  • Villani A; Department of Pediatrics, Children's Hospital V Buzzi, University of Milan, Via Lodovico Castelvetro 32, 20154, Milan, Italy.
  • Ravelli A; University of Brescia, P.zza Del Mercato 15, Brescia, Italy.
Ital J Pediatr ; 47(1): 24, 2021 Feb 08.
Article in English | MEDLINE | ID: covidwho-1069577
ABSTRACT

BACKGROUND:

Italy was the first Western country to be hit by the SARS-CoV-2 epidemic. There is now mounting evidence that a minority of children infected with SARS-CoV2 may experience a severe multisystem inflammatory syndrome, called Multisystem inflammatory Syndrome associated with Coronavirus Disease 2019 (MIS-C). To date no universally agreed approach is available for this disease. MAIN BODY as Italy is now facing a second hity of COVID-19 cases, we fear a recrudescence of MIS-C cases. We have, therefore, decided to prepare a report that will help clinicians to face this novel and challenging disease. We propose a diagnostic algorithm, to help case definition and guide work-up, and a therapeutic approach. MIS-C should be promptly recognized, based on the presence of systemic inflammation and specific organ involvement. Early treatment is crucial, and it will be based on the combined use of corticosteroids, high-dose immunoglobulins and anti-cytokine treatments, depending on the severity of the disease. Ancillary treatments (such as. aspirin and thrombo-profilaxis) will be also discussed.

CONCLUSIONS:

we propose a document that will help physicians to diagnose and treat MIS-C patients. Given the level of evidence available and the methodology used, this document should not be interpreted as a guideline; the final decision about the optimal management should still be taken by the caring physician, on an individual basis.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Child / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Ital J Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: S13052-021-00980-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Child / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Ital J Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: S13052-021-00980-2