Neurological involvement of COVID-19: from neuroinvasion and neuroimmune crosstalk to long-term consequences.
Rev Neurosci
; 32(4): 427-442, 2021 06 25.
Article
in English
| MEDLINE | ID: covidwho-1069660
ABSTRACT
As the coronavirus disease 2019 (COVID-19) pandemic continues to be a multidimensional threat to humanity, more evidence of neurological involvement associated with it has emerged. Neuroimmune interaction may prove to be important not only in the pathogenesis of neurological manifestations but also to prevent systemic hyperinflammation. In this review, we summarize reports of COVID-19 cases with neurological involvement, followed by discussion of possible routes of entry, immune responses against coronavirus infection in the central nervous system and mechanisms of nerve degeneration due to viral infection and immune responses. Possible mechanisms for neuroprotection and virus-associated neurological consequences are also discussed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Central Nervous System
/
SARS-CoV-2
/
COVID-19
/
Nervous System Diseases
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Rev Neurosci
Journal subject:
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
Revneuro-2020-0092
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