Your browser doesn't support javascript.
Effects of Environmental Factors on Severity and Mortality of COVID-19.
Kifer, Domagoj; Bugada, Dario; Villar-Garcia, Judit; Gudelj, Ivan; Menni, Cristina; Sudre, Carole; Vuckovic, Frano; Ugrina, Ivo; Lorini, Luca F; Posso, Margarita; Bettinelli, Silvia; Ughi, Nicola; Maloberti, Alessandro; Epis, Oscar; Giannattasio, Cristina; Rossetti, Claudio; Kalogjera, Livije; Persec, Jasminka; Ollivere, Luke; Ollivere, Benjamin J; Yan, Huadong; Cai, Ting; Aithal, Guruprasad P; Steves, Claire J; Kantele, Anu; Kajova, Mikael; Vapalahti, Olli; Sajantila, Antti; Wojtowicz, Rafal; Wierzba, Waldemar; Krol, Zbigniew; Zaczynski, Artur; Zycinska, Katarina; Postula, Marek; Luksic, Ivica; Civljak, Rok; Markotic, Alemka; Brachmann, Johannes; Markl, Andreas; Mahnkopf, Christian; Murray, Benjamin; Ourselin, Sebastien; Valdes, Ana M; Horcajada, Juan P; Castells, Xavier; Pascual, Julio; Allegri, Massimo; Primorac, Dragan; Spector, Tim D; Barrios, Clara.
  • Kifer D; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
  • Bugada D; Emergency and Intensive Care Department, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Hospital, Bergamo, Italy.
  • Villar-Garcia J; Hospital del Mar-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.
  • Gudelj I; Genos Glycoscience Research Laboratory, Zagreb, Croatia.
  • Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  • Sudre C; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  • Vuckovic F; Genos Glycoscience Research Laboratory, Zagreb, Croatia.
  • Ugrina I; Faculty of Science, University of Split, Split, Croatia.
  • Lorini LF; Emergency and Intensive Care Department, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Hospital, Bergamo, Italy.
  • Posso M; Hospital del Mar-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.
  • Bettinelli S; Emergency and Intensive Care Department, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Hospital, Bergamo, Italy.
  • Ughi N; Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Maloberti A; Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Epis O; School of Medicine and Surgery, Milano-Bicocca University, Milan, Italy.
  • Giannattasio C; Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Rossetti C; Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Kalogjera L; School of Medicine and Surgery, Milano-Bicocca University, Milan, Italy.
  • Persec J; Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Ollivere L; Department of Otolaryngology-Head and Neck Surgery, Zagreb School of Medicine, University Hospital Centre "Sestre milosrdnice", Zagreb, Croatia.
  • Ollivere BJ; Clinical Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Hospital Dubrava Zagreb, Zagreb, Croatia.
  • Yan H; University of Zagreb School of Dental Medicine, Zagreb, Croatia.
  • Cai T; National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals National Health Service Trust and the University of Nottingham, Nottingham, United Kingdom.
  • Aithal GP; National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals National Health Service Trust and the University of Nottingham, Nottingham, United Kingdom.
  • Steves CJ; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Department of Infectious Diseases, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Kantele A; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China.
  • Kajova M; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Department of Infectious Diseases, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Vapalahti O; National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals National Health Service Trust and the University of Nottingham, Nottingham, United Kingdom.
  • Sajantila A; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  • Wojtowicz R; Inflammation Centre, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Wierzba W; Inflammation Centre, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Krol Z; Department of Virology, Helsingin ja Uudenmaan Sairaanhoitopiiri Diagnostic Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Zaczynski A; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
  • Zycinska K; Department of Forensic Medicine, University of Helsinki, Helsinki, Finland.
  • Postula M; Forensic Medicine Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Luksic I; Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland.
  • Civljak R; Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland.
  • Markotic A; Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland.
  • Brachmann J; Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland.
  • Markl A; Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland.
  • Mahnkopf C; Medical University of Warsaw, Warsaw, Poland.
  • Murray B; Department of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of Warsaw, Warsaw, Poland.
  • Ourselin S; University of Zagreb School of Medicine, University Hospital Dubrava, Zagreb, Croatia.
  • Valdes AM; University Hospital for Infectious Diseases "Fran Mihaljevic", University of Zagreb School of Medicine, Zagreb, Croatia.
  • Horcajada JP; University Hospital for Infectious Diseases "Fran Mihaljevic", Catholic University of Croatia, Zagreb, Croatia.
  • Castells X; Medical School, University of Rijeka, Rijeka, Croatia.
  • Pascual J; University Hospital for Infectious Diseases "Fran Mihaljevic", University of Zagreb School of Medicine, Zagreb, Croatia.
  • Allegri M; REGIOMED Kliniken, Coburg, Germany.
  • Primorac D; University of Split School of Medicine, Split, Croatia.
  • Spector TD; REGIOMED Kliniken, Coburg, Germany.
  • Barrios C; REGIOMED Kliniken, Coburg, Germany.
Front Med (Lausanne) ; 7: 607786, 2020.
Article in English | MEDLINE | ID: covidwho-1069727
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT

Background:

Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented.

Methods:

We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application.

Findings:

Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973-0.988, p < 0.001) and per increase in ambient temperature of 1°C to be 0.854 (0.773-0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time.

Interpretation:

Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Reviews Language: English Journal: Front Med (Lausanne) Year: 2020 Document Type: Article Affiliation country: Fmed.2020.607786

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Reviews Language: English Journal: Front Med (Lausanne) Year: 2020 Document Type: Article Affiliation country: Fmed.2020.607786