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COVID-19 and Pediatric Lung Disease: A South African Tertiary Center Experience.
Gray, Diane M; Davies, Mary-Ann; Githinji, Leah; Levin, Michael; Mapani, Muntanga; Nowalaza, Zandiswa; Washaya, Norbertta; Yassin, Aamir; Zampoli, Marco; Zar, Heather J; Vanker, Aneesa.
  • Gray DM; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
  • Davies MA; Medical Research Council (MRC) Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
  • Githinji L; School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
  • Levin M; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
  • Mapani M; Medical Research Council (MRC) Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
  • Nowalaza Z; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
  • Washaya N; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
  • Yassin A; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
  • Zampoli M; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
  • Zar HJ; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
  • Vanker A; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Front Pediatr ; 8: 614076, 2020.
Article in English | MEDLINE | ID: covidwho-1069741
Semantic information from SemMedBD (by NLM)
1. Lung LOCATION_OF Pediatric Disorder
Subject
Lung
Predicate
LOCATION_OF
Object
Pediatric Disorder
2. COVID-19 AFFECTS Reaching
Subject
COVID-19
Predicate
AFFECTS
Object
Reaching
3. Chronic lung disease PROCESS_OF Child
Subject
Chronic lung disease
Predicate
PROCESS_OF
Object
Child
4. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
5. Hospital admission TREATS Viral lower respiratory infection
Subject
Hospital admission
Predicate
TREATS
Object
Viral lower respiratory infection
6. Chest medicine service TREATS Child
Subject
Chest medicine service
Predicate
TREATS
Object
Child
7. Tracheostomy procedure NEG_COEXISTS_WITH Hospital admission
Subject
Tracheostomy procedure
Predicate
NEG_COEXISTS_WITH
Object
Hospital admission
8. Lung Disease PROCESS_OF C0008059
Subject
Lung Disease
Predicate
PROCESS_OF
Object
C0008059
9. Decreased Immunologic Activity [PE] PROCESS_OF Child
Subject
Decreased Immunologic Activity [PE]
Predicate
PROCESS_OF
Object
Child
10. Lung LOCATION_OF Pediatric Disorder
Subject
Lung
Predicate
LOCATION_OF
Object
Pediatric Disorder
11. COVID-19 AFFECTS Reaching
Subject
COVID-19
Predicate
AFFECTS
Object
Reaching
12. Chronic lung disease PROCESS_OF Child
Subject
Chronic lung disease
Predicate
PROCESS_OF
Object
Child
13. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
14. Hospital admission TREATS Viral lower respiratory infection
Subject
Hospital admission
Predicate
TREATS
Object
Viral lower respiratory infection
15. Chest medicine service TREATS Child
Subject
Chest medicine service
Predicate
TREATS
Object
Child
16. Tracheostomy procedure NEG_COEXISTS_WITH Hospital admission
Subject
Tracheostomy procedure
Predicate
NEG_COEXISTS_WITH
Object
Hospital admission
17. Lung Diseases, Interstitial PROCESS_OF Child
Subject
Lung Diseases, Interstitial
Predicate
PROCESS_OF
Object
Child
18. Decreased Immunologic Activity [PE] PROCESS_OF Child
Subject
Decreased Immunologic Activity [PE]
Predicate
PROCESS_OF
Object
Child
ABSTRACT
The COVID-19 pandemic led to rapid global spread with far-reaching impacts on health-care systems. Whilst pediatric data consistently shown a milder disease course, chronic lung disease has been identified as a risk factor for hospitalization and severe disease. In Africa, comprised predominantly of low middle-income countries (LMIC), the additional burden of HIV, tuberculosis, malnutrition and overcrowding is high and further impacts health risk. This paper reviewed the literature on COVID-19 and chronic lung disease in children and provides our experience from an African pediatric pulmonary center in Cape Town, South Africa. South African epidemiological data confirms a low burden of severe disease with children <18 years comprising 8% of all diagnosed cases and 3% of all COVID-19 admissions. A decrease in hospital admission for other viral lower respiratory tract infections was found. While the pulmonology service manages children with a wide range of chronic respiratory conditions including bronchiectasis, cystic fibrosis, asthma, interstitial lung disease and children with tracheostomies, no significant increase in COVID-19 admissions were noted and in those who developed COVID-19, the disease course was not severe. Current evidence suggests that pre-existing respiratory disease in children does not appear to be a significant risk factor for severe COVID-19. Longitudinal data are still needed to assess risk in children with immunosuppression and interstitial lung diseases. The indirect impacts of the pandemic response on child respiratory health are notable and still likely to be fully realized and quantified. Ensuring children have access to full preventive and care services during this time is priority.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Pediatr Year: 2020 Document Type: Article Affiliation country: Fped.2020.614076

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Pediatr Year: 2020 Document Type: Article Affiliation country: Fped.2020.614076