Your browser doesn't support javascript.
Prolonged SARS-CoV-2-RNA Detection from Nasopharyngeal Swabs in an Oncologic Patient: What Impact on Cancer Treatment?
Ferrari, Anna; Trevenzoli, Marco; Sasset, Lolita; Di Liso, Elisabetta; Tavian, Toni; Rossi, Lucia; Di Meco, Eugenia; Cattelan, Anna Maria.
  • Ferrari A; Infectious Diseases Unit, Azienda Ospedale Università di Padova, 35128 Padova, Italy.
  • Trevenzoli M; Infectious Diseases Unit, Azienda Ospedale Università di Padova, 35128 Padova, Italy.
  • Sasset L; Infectious Diseases Unit, Azienda Ospedale Università di Padova, 35128 Padova, Italy.
  • Di Liso E; Medical Oncology 2, Istituto Oncologico Veneto IRCCS, 35128 Padova, Italy.
  • Tavian T; Department of Medicine, Geriatric Clinic, Università di Padova, 35128 Padova, Italy.
  • Rossi L; Microbiology Department, Azienda Ospedale Università di Padova, 35128 Padova, Italy.
  • Di Meco E; Infectious Diseases Unit, Azienda Ospedale Università di Padova, 35128 Padova, Italy.
  • Cattelan AM; Infectious Diseases Unit, Azienda Ospedale Università di Padova, 35128 Padova, Italy.
Curr Oncol ; 28(1): 847-852, 2021 02 08.
Article in English | MEDLINE | ID: covidwho-1069796
ABSTRACT
The pandemic of SARS-CoV-2 is a serious global challenge affecting millions of people worldwide. Cancer patients are at risk for infection exposure and serious complications. A prompt diagnosis of SARS-CoV-2 infection is crucial for the timely adoption of isolation measures and the appropriate management of cancer treatments. In lung cancer patients the symptoms of infection 19 may resemble those exhibited by the underlying oncologic condition, possibly leading to diagnostic overlap and delays. Moreover, cancer patients might display a prolonged positivity of nasopharyngeal RT-PCR assays for SARS-CoV-2, causing long interruptions or delay of cancer treatments. However, the association between the positivity of RT-PCR assays and the patient's infectivity remains uncertain. We describe the case of a patient with non-small cell lung cancer, and a severe ab extrinseco compression of the trachea, whose palliative radiotherapy was delayed because of the prolonged positivity of nasopharyngeal swabs for SARS-CoV-2. The patient did not show clinical symptoms suggestive of active infection, but the persistent positivity of RT-PCR assays imposed the continuation of isolation measures and the delay of radiotherapy for over two months. Finally, the negative result of SARS-CoV-2 viral culture allowed us to verify the absence of viral activity and to rule out the infectivity of the patient, who could finally continue her cancer treatment.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / SARS-CoV-2 / COVID-19 / Lung Neoplasms Type of study: Case report / Diagnostic study / Experimental Studies / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans Language: English Journal: Curr Oncol Year: 2021 Document Type: Article Affiliation country: Curroncol28010083

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / SARS-CoV-2 / COVID-19 / Lung Neoplasms Type of study: Case report / Diagnostic study / Experimental Studies / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans Language: English Journal: Curr Oncol Year: 2021 Document Type: Article Affiliation country: Curroncol28010083