Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome.
Nutrients
; 13(2)2021 Feb 04.
Article
in English
| MEDLINE | ID: covidwho-1069851
ABSTRACT
Post-viral fatigue syndrome (PVFS) is a widespread chronic neurological disease with no definite etiological factor(s), no actual diagnostic test, and no approved pharmacological treatment, therapy, or cure. Among other features, PVFS could be accompanied by various irregularities in creatine metabolism, perturbing either tissue levels of creatine in the brain, the rates of phosphocreatine resynthesis in the skeletal muscle, or the concentrations of the enzyme creatine kinase in the blood. Furthermore, supplemental creatine and related guanidino compounds appear to impact both patient- and clinician-reported outcomes in syndromes and maladies with chronic fatigue. This paper critically overviews the most common disturbances in creatine metabolism in various PVFS populations, summarizes human trials on dietary creatine and creatine analogs in the syndrome, and discusses new frontiers and open questions for using creatine in a post-COVID-19 world.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Fatigue Syndrome, Chronic
/
Creatine
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
/
Traditional medicine
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
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