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Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection.
Vogel-González, Marina; Talló-Parra, Marc; Herrera-Fernández, Víctor; Pérez-Vilaró, Gemma; Chillón, Miguel; Nogués, Xavier; Gómez-Zorrilla, Silvia; López-Montesinos, Inmaculada; Arnau-Barrés, Isabel; Sorli-Redó, Maria Luisa; Horcajada, Juan Pablo; García-Giralt, Natalia; Pascual, Julio; Díez, Juana; Vicente, Rubén; Güerri-Fernández, Robert.
  • Vogel-González M; Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
  • Talló-Parra M; Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
  • Herrera-Fernández V; Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
  • Pérez-Vilaró G; Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
  • Chillón M; Department of Biochemistry and Molecular Biology and Institute of Neurosciences, Edifici H, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
  • Nogués X; Unitat Mixta UAB-VHIR, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
  • Gómez-Zorrilla S; Institut Català de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.
  • López-Montesinos I; Department of Internal Medicine, Hospital del Mar, Institut Mar d'Investigacions Mediques, 08003 Barcelona, Spain.
  • Arnau-Barrés I; Department of Infectious Diseases, Hospital del Mar, Institut Mar d'Investigacions Mediques, 08003 Barcelona, Spain.
  • Sorli-Redó ML; Department of Infectious Diseases, Hospital del Mar, Institut Mar d'Investigacions Mediques, 08003 Barcelona, Spain.
  • Horcajada JP; Department of Infectious Diseases, Hospital del Mar, Institut Mar d'Investigacions Mediques, 08003 Barcelona, Spain.
  • García-Giralt N; Department of Infectious Diseases, Hospital del Mar, Institut Mar d'Investigacions Mediques, 08003 Barcelona, Spain.
  • Pascual J; Department of Infectious Diseases, Hospital del Mar, Institut Mar d'Investigacions Mediques, 08003 Barcelona, Spain.
  • Díez J; Department of Internal Medicine, Hospital del Mar, Institut Mar d'Investigacions Mediques, 08003 Barcelona, Spain.
  • Vicente R; Department of Nephrology, Hospital del Mar, Institut Mar d'Investigacions Mediques, Autonomous University of Barcelona, 08003 Barcelona, Spain.
  • Güerri-Fernández R; Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Nutrients ; 13(2)2021 Feb 09.
Article in English | MEDLINE | ID: covidwho-1069852
ABSTRACT

BACKGROUND:

Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker.

METHODS:

We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations.

FINDINGS:

Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 µg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells.

INTERPRETATION:

Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Zinc / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Nu13020562

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Zinc / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Nu13020562