COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US.
Alzheimers Dement
; 17(8): 1297-1306, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1070694
ABSTRACT
INTRODUCTION:
At present, there is limited data on the risks, disparity, and outcomes for COVID-19 in patients with dementia in the United States.METHODS:
This is a retrospective case-control analysis of patient electronic health records (EHRs) of 61.9 million adult and senior patients (age ≥ 18 years) in the United States up to August 21, 2020.RESULTS:
Patients with dementia were at increased risk for COVID-19 compared to patients without dementia (adjusted odds ratio [AOR] 2.00 [95% confidence interval (CI), 1.94-2.06], P < .001), with the strongest effect for vascular dementia (AOR 3.17 [95% CI, 2.97-3.37], P < .001), followed by presenile dementia (AOR 2.62 [95% CI, 2.28-3.00], P < .001), Alzheimer's disease (AOR 1.86 [95% CI, 1.77-1.96], P < .001), senile dementia (AOR 1.99 [95% CI, 1.86-2.13], P < .001) and post-traumatic dementia (AOR 1.67 [95% CI, 1.51-1.86] P < .001). Blacks with dementia had higher risk of COVID-19 than Whites (AOR 2.86 [95% CI, 2.67-3.06], P < .001). The 6-month mortality and hospitalization risks in patients with dementia and COVID-19 were 20.99% and 59.26%, respectively.DISCUSSION:
These findings highlight the need to protect patients with dementia as part of the strategy to control the COVID-19 pandemic.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dementia
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Country/Region as subject:
North America
Language:
English
Journal:
Alzheimers Dement
Year:
2021
Document Type:
Article
Affiliation country:
Alz.12296
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