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[Mortality in sepsis and septic shock in Germany. Results of a systematic review and meta-analysis]. / Sterblichkeit bei Sepsis und septischem Schock in Deutschland. Ergebnisse eines systematischen Reviews mit Metaanalyse.
Bauer, Michael; Groesdonk, Heinrich Volker; Preissing, Franziska; Dickmann, Petra; Vogelmann, Tobias; Gerlach, Herwig.
  • Bauer M; Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland. Michael.Bauer@med.uni-jena.de.
  • Groesdonk HV; Klinik für Interdisziplinäre Intensivmedizin und Intermediate Care, Helios Klinikum Erfurt, Nordhäuser Straße 74, 99089, Erfurt, Deutschland.
  • Preissing F; CytoSorbents Europe GmbH, Müggelseedamm 131, 12587, Berlin, Deutschland.
  • Dickmann P; Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.
  • Vogelmann T; LinkCare GmbH, Kyffhäuserstr. 64, 70469, Stuttgart, Deutschland.
  • Gerlach H; Klinik für Anästhesie, operative Intensivmedizin und Schmerztherapie, Vivantes Klinikum Neukölln, Rudower Straße 48, 12351, Berlin, Deutschland.
Anaesthesist ; 70(8): 673-680, 2021 Aug.
Article in German | MEDLINE | ID: covidwho-1070812
Semantic information from SemMedBD (by NLM)
1. Septic Shock PROCESS_OF Patients
Subject
Septic Shock
Predicate
PROCESS_OF
Object
Patients
2. Septicemia PROCESS_OF Patients
Subject
Septicemia
Predicate
PROCESS_OF
Object
Patients
3. Severe Sepsis PROCESS_OF Patients
Subject
Severe Sepsis
Predicate
PROCESS_OF
Object
Patients
4. Septic Shock PROCESS_OF Patients
Subject
Septic Shock
Predicate
PROCESS_OF
Object
Patients
5. Septicemia PROCESS_OF Patients
Subject
Septicemia
Predicate
PROCESS_OF
Object
Patients
6. Severe Sepsis PROCESS_OF Patients
Subject
Severe Sepsis
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

BACKGROUND:

The reported mortality for sepsis and septic shock varies between 15% and 59% in international comparison. For Germany, the number of studies is limited. Previous estimations of mortality in Germany are outdated or based on claims data analyses. Various authors discuss whether lacking quality initiatives and treatment standards in Germany could cause higher mortality for sepsis. This contrasts with the internationally well-recognized performance of the German intensive care infrastructure during the COVID-19 pandemic.

OBJECTIVES:

The objectives of this systematic review and meta-analysis were to estimate 30-day and 90-day mortality of patients with sepsis and patients with septic shock in Germany and to compare the mortality with that of other industrialized regions (Europe, North America). MATERIAL AND

METHODS:

A systematic literature search included interventional and observational studies published between 2009 and 2020 in PubMed and the Cochrane Library that analyzed adult patients with sepsis, severe sepsis and septic shock in Europe and North America. Studies with less than 20 patients were excluded. The 30-day and 90-day mortality for sepsis and septic shock were pooled separately for studies conducted in Germany, Europe (excluding Germany) and North America in a meta-analysis using a random effects model. Mortality over time was analyzed in a linear regression model.

RESULTS:

Overall, 134 studies were included. Of these, 15 studies were identified for the estimation of mortality in Germany, covering 10,434 patients, the number of patients per study ranged from 28 to 4183 patients. The 30-day mortality for sepsis was 26.50% (95% confidence interval, CI 19.86-33.15%) in Germany, 23.85% (95% CI 20.49-27.21%) in Europe (excluding Germany) and 19.58% (95% CI 14.03-25.14%) in North America. The 30-day mortality for septic shock was 30.48% (95% CI 29.30-31.67%) in Germany, 34.57% (95% CI 33.51-35.64%) in Europe (excluding Germany) and 33.69% (95% CI 31.51-35.86%) in North America. The 90-day mortality for septic shock was 38.78% (95% CI 32.70-44.86%) in Germany, 41.90% (95% CI 38.88-44.91%) in Europe (excluding Germany) and 34.41% (95% CI 25.66-43.16%) in North America. A comparable decreasing trend in sepsis 30-day mortality was observed in all considered regions since 2009.

CONCLUSION:

Our analysis does not support the notion that mortality related to sepsis and septic shock in Germany is higher in international comparison. A higher mortality would not be obvious either, since intensive care, for example also during the COVID-19 pandemic, is regarded as exemplary in Germany and the structural quality, such as the number of intensive care beds per 100,000 inhabitants, is high in international comparison. Nevertheless, deficits could also exist outside intensive care medicine. A comparison of international individual studies should take greater account of the structure of healthcare systems, the severity of disease and the limitations resulting from the data sources used.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Shock, Septic / Sepsis Type of study: Clinical Practice Guide / Randomized controlled trials / Reviews / Systematic review Limits: Adult / Humans Country/Region as subject: Europa Language: German Journal: Anaesthesist Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Shock, Septic / Sepsis Type of study: Clinical Practice Guide / Randomized controlled trials / Reviews / Systematic review Limits: Adult / Humans Country/Region as subject: Europa Language: German Journal: Anaesthesist Year: 2021 Document Type: Article