[COVID-19: effects on the lungs and heart]. / COVID-19: Auswirkungen auf Lunge und Herz.
Pathologe
; 42(2): 164-171, 2021 Mar.
Article
in German
| MEDLINE | ID: covidwho-1235729
ABSTRACT
Viral respiratory diseases constitute the most common reasons for hospitalization with more than half of all acute illnesses worldwide. Progressive respiratory failure with pronounced diffuse alveolar damage has been identified as the primary cause of death in COVID-19. COVID-19 pneumonia shares common histopathological hallmarks with influenza (H1N1)-related ARDS, like diffuse alveolar damage (DAD) with edema, hemorrhage, and intra-alveolar fibrin deposition. The lungs with COVID-19 pneumonia revealed perivascular inflammation, an endothelial injury, microangiopathy, and an aberrant blood vessel neoformation by intussusceptive angiogenesis. While this pronounced angiocentric inflammation is likely be found - to varying degrees - in numerous other organs, e.g., the heart, COVID-19 is hypothesized to be not just a pulmonary, but rather a systemic "vascular disease."
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Influenza A Virus, H1N1 Subtype
/
COVID-19
Type of study:
Experimental Studies
Limits:
Humans
Language:
German
Journal:
Pathologe
Year:
2021
Document Type:
Article
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