A certain proportion of docosahexaenoic acid tends to revert structural and dynamical effects of cholesterol on lipid membranes.
Biochim Biophys Acta Biomembr
; 1863(6): 183584, 2021 06 01.
Article
in English
| MEDLINE | ID: covidwho-1071093
ABSTRACT
This work investigates how docosahexaenoic acid (DHA) modifies the effect of Cholesterol (Chol) on the structural and dynamical properties of dipalmitoylphosphatidylcholine (DPPC) membrane. We employ low-cost and non-invasive methods:
zeta potential (ZP), conductivity, density, and ultrasound velocity, complemented by molecular dynamics simulations. Our studies reveal that 30% of DHA added to the DPPC-Chol system tends to revert Chol action on a model lipid bilayer. Results obtained in this work shed light on the effect of polyunsaturated fatty acids - particularly DHA - on lipid membranes, with potential preventive applications in many diseases, e.g. neuronal as, Alzheimer's disease, and viral, as Covid-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Phosphatidylcholines
/
Docosahexaenoic Acids
/
Cholesterol
/
Lipid Bilayers
Type of study:
Experimental Studies
Language:
English
Journal:
Biochim Biophys Acta Biomembr
Year:
2021
Document Type:
Article
Affiliation country:
J.bbamem.2021.183584
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