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Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection.
Anderson, Elizabeth M; Goodwin, Eileen C; Verma, Anurag; Arevalo, Claudia P; Bolton, Marcus J; Weirick, Madison E; Gouma, Sigrid; McAllister, Christopher M; Christensen, Shannon R; Weaver, JoEllen; Hicks, Philip; Manzoni, Tomaz B; Oniyide, Oluwatosin; Ramage, Holly; Mathew, Divij; Baxter, Amy E; Oldridge, Derek A; Greenplate, Allison R; Wu, Jennifer E; Alanio, Cécile; D'Andrea, Kurt; Kuthuru, Oliva; Dougherty, Jeanette; Pattekar, Ajinkya; Kim, Justin; Han, Nicholas; Apostolidis, Sokratis A; Huang, Alex C; Vella, Laura A; Kuri-Cervantes, Leticia; Pampena, M Betina; Betts, Michael R; Wherry, E John; Meyer, Nuala J; Cherry, Sara; Bates, Paul; Rader, Daniel J; Hensley, Scott E.
  • Anderson EM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Goodwin EC; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Arevalo CP; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Bolton MJ; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Weirick ME; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Gouma S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • McAllister CM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Christensen SR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Weaver J; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hicks P; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Manzoni TB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Oniyide O; Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Ramage H; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Mathew D; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Baxter AE; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Oldridge DA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Greenplate AR; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Wu JE; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, Perelman School of Me
  • Alanio C; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, Perelman School of Me
  • D'Andrea K; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kuthuru O; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Dougherty J; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Pattekar A; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kim J; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Han N; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Apostolidis SA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Huang AC; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Vella LA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Infectious Diseases, Department of Pediatrics, Child
  • Kuri-Cervantes L; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Pampena MB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Wherry EJ; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, Perelman School of Me
  • Meyer NJ; Division of Pulmonary, Allergy, and Critical Care Medicine and Center for Translational Lung Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Cherry S; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Bates P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Center for Research on Coronavirus and Other Emerging Pathogens, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hensley SE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: hensley@pennmedicine.upenn.edu.
Cell ; 184(7): 1858-1864.e10, 2021 04 01.
Article in English | MEDLINE | ID: covidwho-1071140
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
Semantic information from SemMedBD (by NLM)
1. Antibodies PART_OF Human coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
Human coronavirus
2. Antibodies AFFECTS COVID-19
Subject
Antibodies
Predicate
AFFECTS
Object
COVID-19
3. Specimen Type - Serum LOCATION_OF Antibodies
Subject
Specimen Type - Serum
Predicate
LOCATION_OF
Object
Antibodies
4. Cohort LOCATION_OF Serum
Subject
Cohort
Predicate
LOCATION_OF
Object
Serum
5. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
6. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
7. Serum LOCATION_OF Antibodies
Subject
Serum
Predicate
LOCATION_OF
Object
Antibodies
8. Serum PART_OF hospitalized patients
Subject
Serum
Predicate
PART_OF
Object
hospitalized patients
9. Antibodies NEG_PREVENTS COVID-19
Subject
Antibodies
Predicate
NEG_PREVENTS
Object
COVID-19
10. Antibodies PART_OF Human coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
Human coronavirus
11. Antibodies AFFECTS COVID-19
Subject
Antibodies
Predicate
AFFECTS
Object
COVID-19
12. Specimen Type - Serum LOCATION_OF Antibodies
Subject
Specimen Type - Serum
Predicate
LOCATION_OF
Object
Antibodies
13. Cohort LOCATION_OF Serum
Subject
Cohort
Predicate
LOCATION_OF
Object
Serum
14. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
15. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
16. Serum LOCATION_OF Antibodies
Subject
Serum
Predicate
LOCATION_OF
Object
Antibodies
17. Serum PART_OF hospitalized patients
Subject
Serum
Predicate
PART_OF
Object
hospitalized patients
18. Antibodies NEG_PREVENTS COVID-19
Subject
Antibodies
Predicate
NEG_PREVENTS
Object
COVID-19
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been previously exposed to other antigenically distinct common seasonal human coronaviruses (hCoVs) before the coronavirus disease 2019 (COVID-19) pandemic. Here, we quantified levels of SARS-CoV-2-reactive antibodies and hCoV-reactive antibodies in serum samples collected from 431 humans before the COVID-19 pandemic. We then quantified pre-pandemic antibody levels in serum from a separate cohort of 251 individuals who became PCR-confirmed infected with SARS-CoV-2. Finally, we longitudinally measured hCoV and SARS-CoV-2 antibodies in the serum of hospitalized COVID-19 patients. Our studies indicate that most individuals possessed hCoV-reactive antibodies before the COVID-19 pandemic. We determined that ∼20% of these individuals possessed non-neutralizing antibodies that cross-reacted with SARS-CoV-2 spike and nucleocapsid proteins. These antibodies were not associated with protection against SARS-CoV-2 infections or hospitalizations, but they were boosted upon SARS-CoV-2 infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Alphacoronavirus / Betacoronavirus / COVID-19 / Antibodies, Viral Type of study: Randomized controlled trials / Risk factors Limits: Adolescent / Adult / Animals / Child / Child, preschool / Humans / Infant / Infant, Newborn Language: English Journal: Cell Year: 2021 Document Type: Article Affiliation country: J.cell.2021.02.010

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Alphacoronavirus / Betacoronavirus / COVID-19 / Antibodies, Viral Type of study: Randomized controlled trials / Risk factors Limits: Adolescent / Adult / Animals / Child / Child, preschool / Humans / Infant / Infant, Newborn Language: English Journal: Cell Year: 2021 Document Type: Article Affiliation country: J.cell.2021.02.010