Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico.
Int J Infect Dis
; 105: 598-605, 2021 Apr.
Article
in English
| MEDLINE | ID: covidwho-1071457
ABSTRACT
OBJECTIVE:
There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and thrombosis related to COVID-19. This study aimed to assess the effectiveness of a multidrug-therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid ("TNR4" therapy) to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. DESIGN ANDMETHODS:
A comparative effectiveness study was performed among 768 confirmed SARS-CoV-2 cases aged 18-80 years, who received ambulatory care at the Ministry of Health of Tlaxcala. A total of 481 cases received the TNR4 therapy, while 287 received another treatment (comparison group). All participants received home visits and/or phone calls for clinical evaluation during the 14 days after enrollment.RESULTS:
Nearly 85% of cases who received the TNR4 recovered within 14 days compared to 59% in the comparison group. The likelihood of recovery within 14 days was 3.4 times greater among the TNR4 group than in the comparison group. Patients treated with TNR4 had a 75% and 81% lower risk of being hospitalized or death, respectively, than the comparison group.CONCLUSIONS:
TNR4 therapy improved recovery and prevented the risk of hospitalization and death among ambulatory COVID-19 cases.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Quinolines
/
Sulfides
/
Ivermectin
/
Aspirin
/
Azithromycin
/
Cyclopropanes
/
COVID-19 Drug Treatment
/
Acetates
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
/
Young adult
Country/Region as subject:
Mexico
Language:
English
Journal:
Int J Infect Dis
Journal subject:
Communicable Diseases
Year:
2021
Document Type:
Article
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