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Epidemiological and clinical characteristics of 214 families with COVID-19 in Wuhan, China.
Yi, Bo; Fen, Gaoke; Cao, Dedong; Cai, Yuli; Qian, Li; Li, Wei; Wen, Zhongyuan; Sun, Xuan.
  • Yi B; Department of Endocrinology, Department of Fever Clinics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Fen G; Department of Cardiology, Department of Fever Clinics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Cao D; Department of Clinical Oncology, Department of Fever Clinics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Cai Y; Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Qian L; Department of Fever Clinics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Li W; Department of Fever Clinics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Wen Z; Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: wenzywurm@163.com.
  • Sun X; Department of Internal Medicine, Department of Fever Clinics, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: 515356928@qq.com.
Int J Infect Dis ; 105: 113-119, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1071459
ABSTRACT

OBJECTIVE:

To investigate the epidemiological dynamics, transmission patterns, and the clinical outcomes of Coronavirus disease 2019 (COVID-19) in familial cluster patients in Wuhan, China.

METHODS:

Between January 22, 2020, and February 4, 2020, we enrolled 214 families for this retrospective study. The COVID-19 cases were diagnosed using real-time reverse-transcriptase polymerase chain reaction (RT-PCR). The number of COVID-19 subjects in a family, their relationship with index patients, the key time-to-event, exposure history, and the clinical outcomes were obtained through telephone calls.

RESULTS:

Overall, 96 families (44.9%) met the criteria of a familial cluster, which is at least one confirmed case in addition to the index patient in the same household. The secondary attack rate was 42.9%, and nearly 95% of index patients transmitted the infection to ≤2 other family members. High transmission pattern was noted between couples (51.0%) and among multi-generations (27.1%). The median serial interval distribution in familial clusters was 5 days (95% CI, 4 to 6). The case fatality rate was 8.7% in index patients and 1.7% in non-familial clusters patients (p = 0.023).

CONCLUSIONS:

There is a related higher attack rate and worse clinical outcomes in COVID-19 family clusters.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.02.021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.02.021