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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.
Xie, Xuping; Liu, Yang; Liu, Jianying; Zhang, Xianwen; Zou, Jing; Fontes-Garfias, Camila R; Xia, Hongjie; Swanson, Kena A; Cutler, Mark; Cooper, David; Menachery, Vineet D; Weaver, Scott C; Dormitzer, Philip R; Shi, Pei-Yong.
  • Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Liu Y; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Liu J; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
  • Zhang X; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Zou J; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Fontes-Garfias CR; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Xia H; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Swanson KA; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Cutler M; Pfizer, Pearl River, NY, USA.
  • Cooper D; Pfizer, Pearl River, NY, USA.
  • Menachery VD; Pfizer, Pearl River, NY, USA.
  • Weaver SC; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
  • Dormitzer PR; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Shi PY; Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Nat Med ; 27(4): 620-621, 2021 04.
Article in English | MEDLINE | ID: covidwho-1072168
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ABSTRACT
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neutralization Tests / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 / Mutation Topics: Vaccines / Variants Limits: Humans Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2021 Document Type: Article Affiliation country: S41591-021-01270-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neutralization Tests / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 / Mutation Topics: Vaccines / Variants Limits: Humans Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2021 Document Type: Article Affiliation country: S41591-021-01270-4