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Scent dog identification of samples from COVID-19 patients - a pilot study.
Jendrny, Paula; Schulz, Claudia; Twele, Friederike; Meller, Sebastian; von Köckritz-Blickwede, Maren; Osterhaus, Albertus Dominicus Marcellinus Erasmus; Ebbers, Janek; Pilchová, Veronika; Pink, Isabell; Welte, Tobias; Manns, Michael Peter; Fathi, Anahita; Ernst, Christiane; Addo, Marylyn Martina; Schalke, Esther; Volk, Holger Andreas.
  • Jendrny P; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Schulz C; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Twele F; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Meller S; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
  • von Köckritz-Blickwede M; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Osterhaus ADME; Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Ebbers J; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Pilchová V; , Hörstel, Germany.
  • Pink I; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Welte T; Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
  • Manns MP; Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
  • Fathi A; Hannover Medical School, Hannover, Germany.
  • Ernst C; Department of Medicine, Division of Infectious Diseases, University Medical-Center Hamburg-Eppendorf, Hamburg, Germany.
  • Addo MM; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
  • Schalke E; German Center for Infection Research, Hamburg-Lübeck, Borstel-Riems, Germany.
  • Volk HA; Central Institute of Medical Service, German Armed Forces, Koblenz, Germany.
BMC Infect Dis ; 20(1): 536, 2020 Jul 23.
Article in English | MEDLINE | ID: covidwho-1072981
ABSTRACT

BACKGROUND:

As the COVID-19 pandemic continues to spread, early, ideally real-time, identification of SARS-CoV-2 infected individuals is pivotal in interrupting infection chains. Volatile organic compounds produced during respiratory infections can cause specific scent imprints, which can be detected by trained dogs with a high rate of precision.

METHODS:

Eight detection dogs were trained for 1 week to detect saliva or tracheobronchial secretions of SARS-CoV-2 infected patients in a randomised, double-blinded and controlled study.

RESULTS:

The dogs were able to discriminate between samples of infected (positive) and non-infected (negative) individuals with average diagnostic sensitivity of 82.63% (95% confidence interval [CI] 82.02-83.24%) and specificity of 96.35% (95% CI 96.31-96.39%). During the presentation of 1012 randomised samples, the dogs achieved an overall average detection rate of 94% (±3.4%) with 157 correct indications of positive, 792 correct rejections of negative, 33 incorrect indications of negative or incorrect rejections of 30 positive sample presentations.

CONCLUSIONS:

These preliminary findings indicate that trained detection dogs can identify respiratory secretion samples from hospitalised and clinically diseased SARS-CoV-2 infected individuals by discriminating between samples from SARS-CoV-2 infected patients and negative controls. This data may form the basis for the reliable screening method of SARS-CoV-2 infected people.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Mass Screening / Coronavirus Infections / Betacoronavirus / Odorants Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: S12879-020-05281-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Mass Screening / Coronavirus Infections / Betacoronavirus / Odorants Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: S12879-020-05281-3