Analysis of the characteristics of hematological parameters in the early stages of COVID-19

ABSTRACT

The aim of the article was to analyze the characteristics of early peripheral blood laboratory examination results of patients with new coronavirus pneumonia (coronavirus disease 2019, COVID-19), and provide references for early clinical identification. From January 11, 2020 to February 18, 2020, all 626 patients who attended the fever clinic of Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology and tested positive for the new coronavirus (SARS-CoV-2) nucleic acid were selected as the research group In addition, 254 suspected patients who visited the fever clinic during the same period and the SARS-CoV-2 nucleic acid test was negative for two or more consecutive times were selected as the control group, and analyzed the blood cell test, biochemical routine, and inflammation markers of the two groups of patients at the fever clinic for the first time. The characteristics of 31 hematological indicators. Compared with the control group, the white blood cell (WBC), lymphocyte (LYMPH), platelet (PLT), serum calcium (serum calcium, Ca) of the study group were significantly reduced, and the hypersensitive C-reactive protein (hypersensitive C-reactive protein, hsCRP) significantly increased, the difference was statistically significant, and there was a difference in the distribution of results. In the study group, WBC was mostly normal or decreased. WBC was normal in 85.3%, decreased in 9.4%, LYMPH decreased in 43.1%, PLT decreased in 12.8%, Ca decreased in 61.8%, hsCRP was higher than 10mg/L accounted for 66.2%. The remaining 26 hematological indicators (Cl, Na, K, HCO3, Urea, UA, Cr, TBA, CHE, ALB, ALT, ALP, LDH, TP, PCT, DBIL, GLB, IBIL, TBIL, P-GGT, TCHOL, AST, Hb, RBC, NEUT, MON) There was no statistically significant difference between the two groups. WBC, LYMPH, PLT, Ca and hsCRP have significant changes in the early stage of COVID-19 patients. Joint detection and observation of the above indicators can provide important references for early clinical identification.