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T Cell Phenotyping in Individuals Hospitalized with COVID-19.
Rupp, Janine; Dreo, Barbara; Gütl, Katharina; Fessler, Johannes; Moser, Adrian; Haditsch, Bernd; Schilcher, Gernot; Matzkies, Lucie-Marie; Steinmetz, Ivo; Greinix, Hildegard; Stradner, Martin H.
  • Rupp J; Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Dreo B; Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Gütl K; Division of Angiology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Fessler J; Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Moser A; Österreichische Gesundheitskasse, Gesundheitszentrum Graz, 8010 Graz, Austria.
  • Haditsch B; Österreichische Gesundheitskasse, Gesundheitszentrum Graz, 8010 Graz, Austria.
  • Schilcher G; Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Matzkies LM; Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, 8036 Graz, Austria; and.
  • Steinmetz I; Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, 8036 Graz, Austria; and.
  • Greinix H; Division of Hematology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Stradner MH; Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; martin.stradner@medunigraz.at.
J Immunol ; 206(7): 1478-1482, 2021 04 01.
Article in English | MEDLINE | ID: covidwho-1073559
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic. Cytokine release syndrome occurring in a minority of SARS-CoV-2 infections is associated with severe disease and high mortality. We profiled the composition, activation, and proliferation of T cells in 20 patients with severe or critical COVID-19 and 40 matched healthy controls by flow cytometry. Unsupervised hierarchical cluster analysis based on 18 T cell subsets resulted in separation of healthy controls and COVID-19 patients. Compared to healthy controls, patients suffering from severe and critical COVID-19 had increased frequencies of activated and proliferating CD38+Ki67+ CD4+ and CD8+ T cells, suggesting active antiviral T cell defense. Frequencies of CD38+Ki67+ Th1 and CD4+ cells correlated negatively with plasma IL-6. Thus, our data suggest that patients suffering from COVID-19 have a distinct T cell composition that is potentially modulated by IL-6.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Th1 Cells / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Immunity, Cellular Type of study: Observational study Limits: Adult / Female / Humans / Male Language: English Journal: J Immunol Year: 2021 Document Type: Article Affiliation country: Jimmunol.2001034

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Th1 Cells / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Immunity, Cellular Type of study: Observational study Limits: Adult / Female / Humans / Male Language: English Journal: J Immunol Year: 2021 Document Type: Article Affiliation country: Jimmunol.2001034