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Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources.
Bovo, Samuele; Schiavo, Giuseppina; Ribani, Anisa; Utzeri, Valerio J; Taurisano, Valeria; Ballan, Mohamad; Muñoz, Maria; Alves, Estefania; Araujo, Jose P; Bozzi, Riccardo; Charneca, Rui; Di Palma, Federica; Djurkin Kusec, Ivona; Etherington, Graham; Fernandez, Ana I; García, Fabián; García-Casco, Juan; Karolyi, Danijel; Gallo, Maurizio; Martins, José Manuel; Mercat, Marie-José; Núñez, Yolanda; Quintanilla, Raquel; Radovic, Cedomir; Razmaite, Violeta; Riquet, Juliette; Savic, Radomir; Skrlep, Martin; Usai, Graziano; Zimmer, Christoph; Ovilo, Cristina; Fontanesi, Luca.
  • Bovo S; Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy.
  • Schiavo G; Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy.
  • Ribani A; Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy.
  • Utzeri VJ; Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy.
  • Taurisano V; Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy.
  • Ballan M; Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy.
  • Muñoz M; Departamento Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria yAlimentaria (INIA), Crta. de la Coruña, km. 7, 5, 28040, Madrid, Spain.
  • Alves E; Departamento Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria yAlimentaria (INIA), Crta. de la Coruña, km. 7, 5, 28040, Madrid, Spain.
  • Araujo JP; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Viana do Castelo, Escola Superior Agrária, Refóios do Lima, 4990-706, Ponte de Lima, Portugal.
  • Bozzi R; DAGRI - Animal Science Section, University of Florence, Via delle Cascine 5, 50144, Florence, Italy.
  • Charneca R; MED - Mediterranean Institute for Agriculture, Environment and Development, Universidade de Évora, Pólo da Mitra, Apartado 94, 7006-554, Évora, Portugal.
  • Di Palma F; Biodiversity School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR47UH, UK.
  • Djurkin Kusec I; Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, Vladimira Preloga 1, 31000, Osijek, Croatia.
  • Etherington G; Earlham Institute, Norwich Research Park, Colney Lane, Norwich, Norfolk, NR47UZ, UK.
  • Fernandez AI; Departamento Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria yAlimentaria (INIA), Crta. de la Coruña, km. 7, 5, 28040, Madrid, Spain.
  • García F; Departamento Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria yAlimentaria (INIA), Crta. de la Coruña, km. 7, 5, 28040, Madrid, Spain.
  • García-Casco J; Departamento Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria yAlimentaria (INIA), Crta. de la Coruña, km. 7, 5, 28040, Madrid, Spain.
  • Karolyi D; Department of Animal Science, Faculty of Agriculture, University of Zagreb, Svetosimunska c. 25, 10000, Zagreb, Croatia.
  • Gallo M; Associazione Nazionale Allevatori Suini (ANAS), Via Nizza 53, 00198, Rome, Italy.
  • Martins JM; MED - Mediterranean Institute for Agriculture, Environment and Development, Universidade de Évora, Pólo da Mitra, Apartado 94, 7006-554, Évora, Portugal.
  • Mercat MJ; IFIP Institut du porc, La Motte au Vicomte, BP 35104, 35651, Le Rheu Cedex, France.
  • Núñez Y; Departamento Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria yAlimentaria (INIA), Crta. de la Coruña, km. 7, 5, 28040, Madrid, Spain.
  • Quintanilla R; Programa de Genética y Mejora Animal, Institute for Research and Technology in Food and Agriculture (IRTA), Torre Marimon, 08140, Caldes de Montbui, Barcelona, Spain.
  • Radovic C; Department of Pig Breeding and Genetics, Institute for Animal Husbandry, 11080, Belgrade-Zemun, Serbia.
  • Razmaite V; Animal Science Institute, Lithuanian University of Health Sciences, Baisogala, Lithuania.
  • Riquet J; Génétique Physiologie et Systèmes d'Elevage (GenPhySE), Université de Toulouse, INRA, Chemin de Borde-Rouge 24, Auzeville Tolosane, 31326, Castanet Tolosan, France.
  • Savic R; Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080, Belgrade-Zemun, Serbia.
  • Skrlep M; Kmetijski Institut Slovenije, Hacquetova 17, 1000, Ljubljana, Slovenia.
  • Usai G; AGRIS SARDEGNA, Loc. Bonassai, 07100, Sassari, Italy.
  • Zimmer C; Bäuerliche Erzeugergemeinschaft Schwäbisch Hall, Schwäbisch Hall, Germany.
  • Ovilo C; Departamento Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria yAlimentaria (INIA), Crta. de la Coruña, km. 7, 5, 28040, Madrid, Spain.
  • Fontanesi L; Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy. luca.fontanesi@unibo.it.
Sci Rep ; 11(1): 3359, 2021 02 09.
Article in English | MEDLINE | ID: covidwho-1074114
ABSTRACT
Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a "One Health" perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a "One Health" perspective that should consider conservation programs of pig genetic resources with twofold

objectives:

(i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genetic Variation / Coronavirus Infections / Sus scrofa Type of study: Prognostic study Topics: Variants Limits: Animals / Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-82956-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genetic Variation / Coronavirus Infections / Sus scrofa Type of study: Prognostic study Topics: Variants Limits: Animals / Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-82956-0