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Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-α Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy.
Tzachor, Asaf; Rozen, Or; Khatib, Soliman; Jensen, Sophie; Avni, Dorit.
  • Tzachor A; Centre for the Study of Existential Risk & Cambridge Global Food Security Research Center, University of Cambridge, Cambridge, UK.
  • Rozen O; Sphingolipids, Active Metabolites and Immune Modulation Laboratory, MIGAL - Galilee Research Institute, Kiryat Shemona, Israel.
  • Khatib S; Natural compounds and analytical chemistry Laboratory, MIGAL - Galilee Research Institute and Tel Hai college, Kiryat Shemona, Israel.
  • Jensen S; MATIS - Food and Biotech Research and Development, Reykjavík, Iceland.
  • Avni D; Sphingolipids, Active Metabolites and Immune Modulation Laboratory, MIGAL - Galilee Research Institute, Kiryat Shemona, Israel. dorita@migal.org.il.
Mar Biotechnol (NY) ; 23(1): 149-155, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1074429
ABSTRACT
An array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequently hypercytokinemia, commonly referred to as a cytokine storm (CS). It is postulated that CS is mainly responsible for critical COVID-19 cases, including acute respiratory distress syndrome (ARDS). Recognizing the therapeutic potential of Spirulina blue-green algae (Arthrospira platensis), in this in vitro stimulation study, LPS-activated macrophages and monocytes were treated with aqueous extracts of Spirulina, cultivated in either natural or controlled light conditions. We report that an extract of photosynthetically controlled Spirulina (LED Spirulina), at a concentration of 0.1 µg/mL, decreases macrophage and monocyte-induced TNF-α secretion levels by over 70% and 40%, respectively. We propose prompt in vivo studies in animal models and human subjects to determine the putative effectiveness of a natural, algae-based treatment for viral CS and ARDS, and explore the potential of a novel anti-TNF-α therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / Cell Extracts / Cytokine Release Syndrome / COVID-19 / Macrophages Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Mar Biotechnol (NY) Journal subject: Biology / Biotechnology Year: 2021 Document Type: Article Affiliation country: S10126-021-10020-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / Cell Extracts / Cytokine Release Syndrome / COVID-19 / Macrophages Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Mar Biotechnol (NY) Journal subject: Biology / Biotechnology Year: 2021 Document Type: Article Affiliation country: S10126-021-10020-z