Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An In Silico Study.
Med Chem
; 18(2): 220-237, 2022.
Article
in English
| MEDLINE | ID: covidwho-1076369
ABSTRACT
BACKGROUND:
The Covid-19 virus emerged a few months ago in China, and infections rapidly escalated into a pandemic.OBJECTIVE:
To date, there is no selective antiviral agent for the management of pathologies associated with covid-19 and the need for an effective agent against it is essential.METHODS:
In this work, two home-made databases from synthetic quinolines and coumarins were virtually docked against viral proteases (3CL and PL), human cell surface proteases (TMPRSS2 and furin) and spike proteins (S1 and S2). Chloroquine, a reference drug without a clear mechanism against coronavirus was also docked on mentioned targets and the binding affinities compared with title compounds.RESULTS:
The best compounds of synthetic coumarins and quinolines for each target were determined. All compounds against all targets showed binding affinity between -5.80 to -8.99 kcal/mol in comparison with the FDA-approved drug, Chloroquine, with binding affinity of -5.7 to -7.98 kcal/mol. Two compounds, quinoline-1 and coumarin-24, were found to be effective on three targets - S2, TMPRSS2 and furin - simultaneously, with good predicted affinity between -7.54 to -8.85 kcal/mol. In silico ADME studies also confirmed good oral absorption for them. Furthermore, PASS prediction was calculated and coumarin-24 had higher probable activity (Pa) than probable inactivity (Pi) with acceptable protease inhibitory as well as good antiviral activity against Hepatitis C virus (HCV), Human immunodeficiency virus (HIV) and influenza.CONCLUSION:
Quinoline-1 and Coumarin-24 have the potential to be used against Covid-19. Hence these agents could be useful in combating covid-19 infection after further in vitro and in vivo studies.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Quinolones
/
COVID-19
/
Antineoplastic Agents
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Med Chem
Journal subject:
Chemistry
Year:
2022
Document Type:
Article
Affiliation country:
1573406417666210208223924
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