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EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro.
Jang, Minsu; Park, Rackhyun; Park, Yea-In; Cha, Yeo-Eun; Yamamoto, Ayane; Lee, Jin I; Park, Junsoo.
  • Jang M; Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
  • Park R; Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
  • Park YI; Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
  • Cha YE; Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
  • Yamamoto A; Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
  • Lee JI; Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
  • Park J; Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea. Electronic address: junsoo@yonsei.ac.kr.
Biochem Biophys Res Commun ; 547: 23-28, 2021 04 02.
Article in English | MEDLINE | ID: covidwho-1077785
Semantic information from SemMedBD (by NLM)
1. Vaccines TREATS 2019 novel coronavirus
Subject
Vaccines
Predicate
TREATS
Object
2019 novel coronavirus
2. Vaccines TREATS Disease
Subject
Vaccines
Predicate
TREATS
Object
Disease
3. polyphenols INHIBITS Peptide Hydrolases
Subject
polyphenols
Predicate
INHIBITS
Object
Peptide Hydrolases
4. epigallocatechin gallate AFFECTS Coronavirus Infections
Subject
epigallocatechin gallate
Predicate
AFFECTS
Object
Coronavirus Infections
5. Coronavirus OC4 CAUSES C0596402
Subject
Coronavirus OC4
Predicate
CAUSES
Object
C0596402
6. Proteins PART_OF Cells
Subject
Proteins
Predicate
PART_OF
Object
Cells
7. Vaccines TREATS 2019 novel coronavirus
Subject
Vaccines
Predicate
TREATS
Object
2019 novel coronavirus
8. Vaccines TREATS Disease
Subject
Vaccines
Predicate
TREATS
Object
Disease
9. polyphenols INHIBITS Peptide Hydrolases
Subject
polyphenols
Predicate
INHIBITS
Object
Peptide Hydrolases
10. epigallocatechin gallate AFFECTS Coronavirus Infections
Subject
epigallocatechin gallate
Predicate
AFFECTS
Object
Coronavirus Infections
11. Coronavirus OC43, Human CAUSES cytotoxicity
Subject
Coronavirus OC43, Human
Predicate
CAUSES
Object
cytotoxicity
12. Proteins PART_OF Cells
Subject
Proteins
Predicate
PART_OF
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Cells
ABSTRACT
COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Tea / Virus Replication / Coronavirus 229E, Human / Coronavirus OC43, Human / Polyphenols Topics: Vaccines Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tea / Virus Replication / Coronavirus 229E, Human / Coronavirus OC43, Human / Polyphenols Topics: Vaccines Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2021 Document Type: Article