EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro.
Biochem Biophys Res Commun
; 547: 23-28, 2021 04 02.
Article
in English
| MEDLINE | ID: covidwho-1077785
ABSTRACT
COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Tea
/
Virus Replication
/
Coronavirus 229E, Human
/
Coronavirus OC43, Human
/
Polyphenols
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Biochem Biophys Res Commun
Year:
2021
Document Type:
Article
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