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People with blood disorders can be more vulnerable during COVID-19 pandemic: A hypothesis paper.
Aydemir, Duygu; Ulusu, Nuriye Nuray.
  • Aydemir D; Koc University, School of Medicine, Rumelifeneri Yolu, Sariyer, 34450, Istanbul, Turkey; Koc University Research Center for Translational Medicine (KUTTAM), Sariyer, 34450, Istanbul, Turkey.
  • Ulusu NN; Koc University, School of Medicine, Rumelifeneri Yolu, Sariyer, 34450, Istanbul, Turkey; Koc University Research Center for Translational Medicine (KUTTAM), Sariyer, 34450, Istanbul, Turkey. Electronic address: nulusu@ku.edu.tr.
Transfus Apher Sci ; 60(3): 103080, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1078214
ABSTRACT
The world has been encountered with COVID-19 pandemic since at the beginning of 2020 and the number of infected people by COVID-19 is increasing every day. Despite various studies conducted by researchers and doctors, no treatment has been developed until now, therefore self-protection and isolation are strongly recommended to stop the spread of the virus. The elderly population and people with chronic diseases such as hypertension, cardiovascular diseases, diabetes, and cancer are categorized as risk groups, however, we suggest that people with hemoglobinopathies or porphyria can be described as risk groups as well. Current in silico studies have revealed that the COVID-19 virus can attack heme and hemoglobin metabolisms which are responsible for the oxygen transport to the tissues, iron metabolism, elevated levels of oxidative stress, and tissue damage. Data of the in silico study have been supported with the biochemistry and hemogram results of the COVID-19 patients, for instance hemoglobin levels decreased and serum ferritin and C-reactive protein levels increased. Indicated biochemistry biomarkers are tightly associated with inflammation, iron overload, and oxidative stress. In conclusion, since people with hemoglobinopathies or porphyria have already impaired heme and hemoglobin metabolism, COVID-19 infection can enhance the adverse effects of impaired hemoglobin metabolism and accelerate the progression of severe symptoms in patients with hemoglobinopathies or porphyria compared to the normal individuals. Thus those people can be considered as a risk group and extra precautions should be applied for them to protect them.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidative Stress / SARS-CoV-2 / COVID-19 / Hematologic Diseases Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Transfus Apher Sci Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: J.transci.2021.103080

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidative Stress / SARS-CoV-2 / COVID-19 / Hematologic Diseases Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Transfus Apher Sci Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: J.transci.2021.103080