Impact of COVID-19 on quality of life in people with epilepsy, and a multinational comparison of clinical and psychological impacts.
Epilepsy Behav
; 117: 107849, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-1078232
ABSTRACT
BACKGROUND:
This study aimed to determine the relationship among the clinical, logistic, and psychological impacts of COVID-19 on people with epilepsy (PWE), and the impact of COVID-19 on the quality of life.METHOD:
This is a cross-sectional anonymized web-based study on PWE, using an online questionnaire to assess the clinical, logistic, and psychological impacts of COVID-19, including Hospital Anxiety Depression Scale (HADS) and Quality of Life in Epilepsy Inventory (QOLIE-31).RESULT:
461 patients were recruited, with a mean age of 39.21⯱â¯15.88â¯years, majority female (50.1%), with focal epilepsy (54.0%), and experienced seizures at least once yearly (62.5%). There were 13.0% experienced seizure worsening during COVID-19 period, which were associated with baseline seizures frequencyâ¯≥â¯1 per month (32.0% vs. 6.2%, pâ¯<â¯0.001), worries of seizure worsening (18.0% vs. 10.9%, pâ¯<â¯0.001), difficulty to go emergency unit (24.4% vs. 10.4%, pâ¯<â¯0.001), AEDs ran out of stock (23.2% vs. 11.6%, pâ¯<â¯0.05), self-adjustment of AED dosages (26.4% vs. 11.3%, pâ¯<â¯0.001), inadequate sleep (22.4% vs. 9.2%, pâ¯<â¯0.001), and stress (23.4% vs.10.1%, pâ¯<â¯0.01). Participants experiencing seizure worsening reported greater anxiety (8.10⯱â¯5.011 vs. 4.84⯱â¯3.989, pâ¯<â¯0.001) and depression (6.05⯱â¯3.868 vs. 3.86⯱â¯3.589, pâ¯<â¯0.001). Logistic regression showed baseline seizures frequency >1 per month (OR, 14.10) followed by anxiety (OR, 3.90), inadequate sleep (OR, 0.37), and treated in UMMC (OR, 0.31) as the predictors for seizure worsening during COVID-19 period. Poorer total QOLIE-31 score was noted in those with seizure worsening (48.01⯱â¯13.040 vs. 62.15⯱â¯15.222, pâ¯<â¯0.001). Stepwise regression highlighted depression as the main negative predictor for quality of life (ßâ¯=â¯-0.372, pâ¯<â¯0.001), followed by anxiety (ßâ¯=â¯-0.345, pâ¯<â¯0.001).CONCLUSION:
A significant number of PWE experienced seizure worsening during COVID-19 period, which was related to the clinical, logistic, and psychological factors. Quality of life was affected by the seizure worsening and the psychological stress.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Epilepsy
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adult
/
Female
/
Humans
/
Middle aged
/
Young adult
Language:
English
Journal:
Epilepsy Behav
Journal subject:
Behavioral Sciences
/
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
J.yebeh.2021.107849
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