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Enhanced Cholesterol-Dependent Hemifusion by Internal Fusion Peptide 1 of SARS Coronavirus-2 Compared to Its N-Terminal Counterpart.
Pattnaik, Gourab Prasad; Bhattacharjya, Surajit; Chakraborty, Hirak.
  • Pattnaik GP; School of Chemistry, Sambalpur University, Jyoti Vihar, Burla, Odisha 768 019, India.
  • Bhattacharjya S; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore.
  • Chakraborty H; School of Chemistry, Sambalpur University, Jyoti Vihar, Burla, Odisha 768 019, India.
Biochemistry ; 60(8): 559-562, 2021 03 02.
Article in English | MEDLINE | ID: covidwho-1078275
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ABSTRACT
Membrane fusion is an important step for the entry of the lipid-sheathed viruses into the host cells. The fusion process is being carried out by fusion proteins present in the viral envelope. The class I virus contains a 20-25 amino acid sequence at its N-terminal of the fusion domain, which is instrumental in fusion and is called as a "fusion peptide". However, severe acute respiratory syndrome (SARS) coronaviruses contain more than one fusion peptide sequences. We have shown that the internal fusion peptide 1 (IFP1) of SARS-CoV-2 is far more efficient than its N-terminal counterpart (FP) to induce hemifusion between small unilamellar vesicles. Moreover, the ability of IFP1 to induce hemifusion formation increases dramatically with growing cholesterol content in the membrane. Interestingly, IFP1 is capable of inducing hemifusion but fails to open the pore.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptide Fragments / Cholesterol / SARS-CoV-2 / Membrane Fusion Limits: Humans Language: English Journal: Biochemistry Year: 2021 Document Type: Article Affiliation country: Acs.biochem.1c00046

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptide Fragments / Cholesterol / SARS-CoV-2 / Membrane Fusion Limits: Humans Language: English Journal: Biochemistry Year: 2021 Document Type: Article Affiliation country: Acs.biochem.1c00046