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Role of IgG against N-protein of SARS-CoV2 in COVID19 clinical outcomes.
Batra, Mayank; Tian, Runxia; Zhang, Chongxu; Clarence, Emile; Sacher, Camila Sofia; Miranda, Justin Nestor; De La Fuente, Justin Rafa O; Mathew, Megan; Green, Desmond; Patel, Sayari; Bastidas, Maria Virginia Perez; Haddadi, Sara; Murthi, Mukunthan; Gonzalez, Miguel Santiago; Kambali, Shweta; Santos, Kayo H M; Asif, Huda; Modarresi, Farzaneh; Faghihi, Mohammad; Mirsaeidi, Mehdi.
  • Batra M; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Tian R; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Zhang C; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Clarence E; School of Medicine, University of Miami, Miami, FL, USA.
  • Sacher CS; School of Medicine, University of Miami, Miami, FL, USA.
  • Miranda JN; School of Medicine, University of Miami, Miami, FL, USA.
  • De La Fuente JRO; School of Medicine, University of Miami, Miami, FL, USA.
  • Mathew M; School of Medicine, University of Miami, Miami, FL, USA.
  • Green D; School of Medicine, University of Miami, Miami, FL, USA.
  • Patel S; School of Medicine, University of Miami, Miami, FL, USA.
  • Bastidas MVP; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Haddadi S; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Murthi M; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Gonzalez MS; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Kambali S; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Santos KHM; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Asif H; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA.
  • Modarresi F; Express Gene Laboratory, Miami, FL, USA.
  • Faghihi M; Express Gene Laboratory, Miami, FL, USA.
  • Mirsaeidi M; Division of Pulmonary and Critical Care, University of Miami, 1600 NW 10th Ave # 7072B, Miami, FL, 33136, USA. msm249@med.miami.edu.
Sci Rep ; 11(1): 3455, 2021 02 10.
Article in English | MEDLINE | ID: covidwho-1078608
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
The Nucleocapsid Protein (N Protein) of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV2) is located in the viral core. Immunoglobulin G (IgG) targeting N protein is detectable in the serum of infected patients. The effect of high titers of IgG against N-protein on clinical outcomes of SARS-CoV2 disease has not been described. We studied 400 RT-PCR confirmed SARS-CoV2 patients to determine independent factors associated with poor outcomes, including Medical Intensive Care Unit (MICU) admission, prolonged MICU stay and hospital admissions, and in-hospital mortality. We also measured serum IgG against the N protein and correlated its concentrations with clinical outcomes. We found that several factors, including Charlson comorbidity Index (CCI), high levels of IL6, and presentation with dyspnea were associated with poor clinical outcomes. It was shown that higher CCI and higher IL6 levels were independently associated with in-hospital mortality. Anti-N protein IgG was detected in the serum of 55 (55%) patients at the time of admission. A high concentration of antibodies, defined as signal to cut off ratio (S/Co) > 1.5 (75 percentile of all measurements), was found in 25 (25%) patients. The multivariable logistic regression models showed that between being an African American, higher CCI, lymphocyte counts, and S/Co ratio > 1.5, only S/Co ratio were independently associated with MICU admission and longer length of stay in hospital. This study recommends that titers of IgG targeting N-protein of SARS-CoV2 at admission is a prognostic factor for the clinical course of disease and should be measured in all patients with SARS-CoV2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-83108-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-83108-0