SARS-CoV-2 genome and antibodies in breastmilk: a systematic review and meta-analysis.
Arch Dis Child Fetal Neonatal Ed
; 106(5): 514-521, 2021 Sep.
Article
in English
| MEDLINE | ID: covidwho-1079041
ABSTRACT
OBJECTIVE:
To systematically review and meta-analyse the rate of SARS-CoV-2 genome identification and the presence of SARS-CoV-2 antibodies in breastmilk of mothers with COVID-19.DESIGN:
A systematic review of studies published between January 2019 and October 2020 without study design or language restrictions.SETTING:
Data sourced from Ovid Embase Classic+Embase, PubMed, Web of Science, Scopus, relevant bibliographies and the John Hopkins University COVID-19 database. PATIENTS Mothers with confirmed COVID-19 and breastmilk tested for SARS-CoV-2 by RT-PCR or for anti-SARS-CoV-2 antibodies. MAIN OUTCOMEMEASURES:
Presence of SARS-CoV-2 genome and antibodies in breastmilk.RESULTS:
We included 50 articles. Twelve out of 183 women from 48 studies were positive for SARS-CoV-2 genome in their breastmilk (pooled proportion 5% (95% CI 2% to 15%; I2=48%)). Six infants (50%) of these 12 mothers tested positive for SARS-CoV-2, with one requiring respiratory support. Sixty-one out of 89 women from 10 studies had anti-SARS-CoV-2 antibody in their breastmilk (pooled proportion 83% (95% CI 32% to 98%; I2=88%)). The predominant antibody detected was IgA.CONCLUSIONS:
SARS-CoV-2 genome presence in breastmilk is uncommon and is associated with mild symptoms in infants. Anti-SARS-CoV-2 antibodies may be a more common finding. Considering the low proportion of SARS-CoV-2 genome detected in breastmilk and its lower virulence, mothers with COVID-19 should be supported to breastfeed.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Breast Feeding
/
COVID-19 Testing
/
SARS-CoV-2
/
COVID-19
/
Milk, Human
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Female
/
Humans
Language:
English
Journal:
Arch Dis Child Fetal Neonatal Ed
Journal subject:
Pediatrics
/
Perinatology
Year:
2021
Document Type:
Article
Affiliation country:
Archdischild-2020-321074
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