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Evaluation of patients with respiratory infections during the first pandemic wave in Germany: characteristics of COVID-19 versus non-COVID-19 patients.
Fink, Nicola; Rueckel, Johannes; Kaestle, Sophia; Schwarze, Vincent; Gresser, Eva; Hoppe, Boj; Rudolph, Jan; Goller, Sophia; Kunz, Wolfgang G; Ricke, Jens; Sabel, Bastian O.
  • Fink N; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany. nicola.fink@med.uni-muenchen.de.
  • Rueckel J; Comprehensive Pneumology Center (CPC-M), German Center for Lung Research (DZL), 81377, Munich, Germany. nicola.fink@med.uni-muenchen.de.
  • Kaestle S; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
  • Schwarze V; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
  • Gresser E; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
  • Hoppe B; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
  • Rudolph J; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
  • Goller S; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
  • Kunz WG; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
  • Ricke J; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
  • Sabel BO; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.
BMC Infect Dis ; 21(1): 167, 2021 Feb 10.
Article in English | MEDLINE | ID: covidwho-1079217
Semantic information from SemMedBD (by NLM)
1. Respiratory Tract Infections PROCESS_OF Patients
Subject
Respiratory Tract Infections
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Cohort
Subject
COVID-19
Predicate
PROCESS_OF
Object
Cohort
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Suspected COVID-19 PROCESS_OF Patients
Subject
Suspected COVID-19
Predicate
PROCESS_OF
Object
Patients
5. X-Ray Computed Tomography DIAGNOSES Lung finding
Subject
X-Ray Computed Tomography
Predicate
DIAGNOSES
Object
Lung finding
6. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
7. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
Predicate
PROCESS_OF
Object
Patients
8. Abnormal Finding PROCESS_OF Patients
Subject
Abnormal Finding
Predicate
PROCESS_OF
Object
Patients
9. COVID-19 NEG_PROCESS_OF Patients
Subject
COVID-19
Predicate
NEG_PROCESS_OF
Object
Patients
10. Respiratory Tract Infections PROCESS_OF Patients
Subject
Respiratory Tract Infections
Predicate
PROCESS_OF
Object
Patients
11. COVID-19 PROCESS_OF Cohort
Subject
COVID-19
Predicate
PROCESS_OF
Object
Cohort
12. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
13. Suspected COVID-19 PROCESS_OF Patients
Subject
Suspected COVID-19
Predicate
PROCESS_OF
Object
Patients
14. X-Ray Computed Tomography DIAGNOSES Lung finding
Subject
X-Ray Computed Tomography
Predicate
DIAGNOSES
Object
Lung finding
15. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
16. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
Predicate
PROCESS_OF
Object
Patients
17. Abnormal Finding PROCESS_OF Patients
Subject
Abnormal Finding
Predicate
PROCESS_OF
Object
Patients
18. COVID-19 NEG_PROCESS_OF Patients
Subject
COVID-19
Predicate
NEG_PROCESS_OF
Object
Patients
ABSTRACT

BACKGROUND:

Characteristics of COVID-19 patients have mainly been reported within confirmed COVID-19 cohorts. By analyzing patients with respiratory infections in the emergency department during the first pandemic wave, we aim to assess differences in the characteristics of COVID-19 vs. Non-COVID-19 patients. This is particularly important regarding the second COVID-19 wave and the approaching influenza season.

METHODS:

We prospectively included 219 patients with suspected COVID-19 who received radiological imaging and RT-PCR for SARS-CoV-2. Demographic, clinical and laboratory parameters as well as RT-PCR results were used for subgroup analysis. Imaging data were reassessed using the following scoring system 0 - not typical, 1 - possible, 2 - highly suspicious for COVID-19.

RESULTS:

COVID-19 was diagnosed in 72 (32,9%) patients. In three of them (4,2%) the initial RT-PCR was negative while initial CT scan revealed pneumonic findings. 111 (50,7%) patients, 61 of them (55,0%) COVID-19 positive, had evidence of pneumonia. Patients with COVID-19 pneumonia showed higher body temperature (37,7 ± 0,1 vs. 37,1 ± 0,1 °C; p = 0.0001) and LDH values (386,3 ± 27,1 vs. 310,4 ± 17,5 U/l; p = 0.012) as well as lower leukocytes (7,6 ± 0,5 vs. 10,1 ± 0,6G/l; p = 0.0003) than patients with other pneumonia. Among abnormal CT findings in COVID-19 patients, 57 (93,4%) were evaluated as highly suspicious or possible for COVID-19. In patients with negative RT-PCR and pneumonia, another third was evaluated as highly suspicious or possible for COVID-19 (14 out of 50; 28,0%). The sensitivity in the detection of patients requiring isolation was higher with initial chest CT than with initial RT-PCR (90,4% vs. 79,5%).

CONCLUSIONS:

COVID-19 patients show typical clinical, laboratory and imaging parameters which enable a sensitive detection of patients who demand isolation measures due to COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / COVID-19 Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-05829-x

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / COVID-19 Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-05829-x