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Modeling the initial phase of SARS-CoV-2 deposition in the respiratory tract mimicked by the 11C radionuclide.
Evangelista, Heitor; Amaral, César; Porto, Luís Cristóvão; Gonçalves Junior, Sérgio J; Delfino Sodré, Eduardo; Nogueira, Juliana; Dos Santos, Angela M G; Cataldo, Marcio; Junger, Daniel.
  • Evangelista H; LARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Amaral C; LARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Porto LC; LDD - Laboratorio de Diagnósticos por DNA, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Gonçalves Junior SJ; HLA - Laboratório de Histocompatibilidade e Criopreservação, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Delfino Sodré E; LARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Nogueira J; LARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Dos Santos AMG; LARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Cataldo M; HLA - Laboratório de Histocompatibilidade e Criopreservação, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
  • Junger D; Draxos Consultoria e Gestão Ambiental Ltda., Rio de Janeiro, Rio de Janeiro, Brazil.
PLoS One ; 16(1): e0245019, 2021.
Article in English | MEDLINE | ID: covidwho-1079325
ABSTRACT
The knowledge on the deposition and retention of the viral particle of SARS-CoV-2 in the respiratory tract during the very initial intake from the ambient air is of prime importance to understand the infectious process and COVID-19 initial symptoms. We propose to use a modified version of a widely tested lung deposition model developed by the ICRP, in the context of the ICRP Publication 66, that provides deposition patterns of microparticles in different lung compartments. In the model, we mimicked the "environmental decay" of the virus, determined by controlled experiments related to normal speeches, by the radionuclide 11C that presents comparable decay rates. Our results confirm clinical observations on the high virus retentions observed in the extrathoracic region and the lesser fraction on the alveolar section (in the order of 5), which may shed light on physiopathology of clinical events as well on the minimal inoculum required to establish infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0245019

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0245019