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VOC 202012/01 Variant Is Effectively Neutralized by Antibodies Produced by Patients Infected before Its Diffusion in Italy.
Rondinone, Valeria; Pace, Lorenzo; Fasanella, Antonio; Manzulli, Viviana; Parisi, Antonio; Capobianchi, Maria Rosaria; Ostuni, Angelo; Chironna, Maria; Caprioli, Elisabetta; Labonia, Maria; Cipolletta, Dora; Della Rovere, Ines; Serrecchia, Luigina; Petruzzi, Fiorenza; Pennuzzi, Germana; Galante, Domenico.
  • Rondinone V; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Pace L; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Fasanella A; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Manzulli V; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Parisi A; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Capobianchi MR; Laboratory of Virology, National Institute for Infectious Diseases "L. Spallanzani", 00149 Roma, Italy.
  • Ostuni A; Transfusional Medicine Unit, University-Hospital Policlinico, 70124 Bari, Italy.
  • Chironna M; Department of Biomedical Sciences and Human Oncology-Hygiene Section, University of Bari "Aldo Moro", 70124 Bari, Italy.
  • Caprioli E; Clinical Pathology Laboratory, "Di Miccoli" Hospital, 70051 Barletta, Italy.
  • Labonia M; Microbiology Laboratory, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
  • Cipolletta D; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Della Rovere I; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Serrecchia L; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Petruzzi F; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Pennuzzi G; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
  • Galante D; Istituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Viruses ; 13(2)2021 02 11.
Article in English | MEDLINE | ID: covidwho-1079723
Semantic information from SemMedBD (by NLM)
1. Patients LOCATION_OF Serum
Subject
Patients
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LOCATION_OF
Object
Serum
2. Serum PART_OF Patients
Subject
Serum
Predicate
PART_OF
Object
Patients
3. Patients LOCATION_OF Serum
Subject
Patients
Predicate
LOCATION_OF
Object
Serum
4. Serum PART_OF Patients
Subject
Serum
Predicate
PART_OF
Object
Patients
ABSTRACT
The coronavirus disease 2019 (Covid-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and presents a global health emergency that needs urgent intervention. Viruses constantly change through mutation, and new variants of a virus are expected to occur over time. In the United Kingdom (UK), a new variant called B.1.1.7 has emerged with an unusually large number of mutations. The aim of this study is to evaluate the level of protection of sera from 12 patients infected and later healed in Apulia Region (Italy) with Covid-19 between March and November 2020, when the English variant was not circulating in this territory yet, against the new VOC 202012/01 variant by seroneutralization assay. The sera of patients had already been tested before, using a virus belonging to the lineage B.1 and showed an antibody neutralizing titer ranging between 1160 and 1320. All the 12 sera donors confirmed the same titers of neutralizing antibodies obtained with a strain belonging to the lineage B.1.1.7 (VOC 202012/01). These data indicate that antibodies produced in subjects infected with variants of Sars-CoV-2 strain before the appearance of the English one, seem to have a neutralizing power also against this variant.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Variants Limits: Animals / Humans Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13020276

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Variants Limits: Animals / Humans Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13020276