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Detection of SARS-CoV-2 in the ocular surface in different phases of COVID-19 patients in Shanghai, China.
Li, Meiyan; Yang, Yaling; He, Taiwen; Wei, Ruoyan; Shen, Yinzhong; Qi, Tangkai; Han, Tian; Song, Zhigang; Zhu, Zhaoqin; Ma, Xiaopeng; Zhao, Jing; Lin, Yixiao; Shen, Yang; Yang, Weiming; Zhao, Keqing; Lu, Hongzhou; Zhou, Xingtao.
  • Li M; Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China.
  • Yang Y; Department of Ophthalmology, Shanghai Public Health Clinical Center, Shanghai, China.
  • He T; Department of Ophthalmology, Shanghai Public Health Clinical Center, Shanghai, China.
  • Wei R; Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China.
  • Shen Y; Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Shanghai, China.
  • Qi T; Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Shanghai, China.
  • Han T; Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China.
  • Song Z; Department of Pathogen Diagnosis and Biosafety, Shanghai Public Health Clinical Center, Shanghai, China.
  • Zhu Z; Department of Laboratory Medicine, Shanghai Public Health Clinical Center, Shanghai, China.
  • Ma X; Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Zhao J; Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China.
  • Lin Y; Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Shanghai, China.
  • Shen Y; Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China.
  • Yang W; Department of Ophthalmology, Children's Hospital of Fudan University, Shanghai, China.
  • Zhao K; Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, China.
  • Lu H; Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Shanghai, China.
  • Zhou X; Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China.
Ann Transl Med ; 9(2): 100, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-1079877
ABSTRACT

BACKGROUND:

To investigate the temporal pattern of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presence on ocular surfaces using conjunctival swabs in coronavirus disease 2019 (COVID-19) patients.

METHODS:

This study included 59 patients (32 newly admitted and 27 hospitalized for ≥2 weeks) with a COVID-19-confirmed diagnosis at the Shanghai Public Health Clinical Center from March 3, 2020, to March 21, 2020. Conjunctival swab samples were collected from both eyes of all the 59 patients and were tested by reverse transcription polymerase chain reaction (RT-PCR) assay. The range of sampling time lies widely between 1 and 50 days since symptom onset.

RESULTS:

Among the 32 newly admitted patients, positive RT-PCR results for SARS-CoV-2 in conjunctival swab samples were reported in 2 patients (one eye for each) without ocular discomfort, but 1 positive case had conjunctival congestion. The positive results were detected on Day 5 for 1 patient and Day 7 for the other, but repeated tests after 1 week were negative for both patients. All 27 patients who had been hospitalized for ≥2 weeks had negative test results. The mean time from symptom onset to sampling of 2 positive cases was significantly less than that of 57 negative cases (P<0.001).

CONCLUSIONS:

SARS-CoV-2 on the ocular surface can be detected in the early phase of COVID-19. The risk of ocular transmission remains and might be higher in the early phase.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Ann Transl Med Year: 2021 Document Type: Article Affiliation country: Atm-20-6026

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Ann Transl Med Year: 2021 Document Type: Article Affiliation country: Atm-20-6026