Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
Emerg Microbes Infect
; 9(1): 386-389, 2020.
Article
in English
| MEDLINE | ID: covidwho-1080
ABSTRACT
In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Virus Shedding
/
Coronavirus Infections
/
Feces
/
Betacoronavirus
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Emerg Microbes Infect
Year:
2020
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS