Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression.
J Clin Exp Hepatol
; 2021 Feb 08.
Article
in English
| MEDLINE | ID: covidwho-1080600
ABSTRACT
OBJECTIVE:
This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association.METHODS:
A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study's main outcome is a poor composite outcome, comprising of mortality and severe COVID-19.RESULTS:
There were 9 studies with 3,663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], p=0.010; I2 56.7%, p=0.018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], p=0.008; I2 57.4%, p=0.029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient -0.04, p=0.033), male gender (coefficient -0.03, p=0.042), and hypertension (coefficient -0.02, p=0.033), but not diabetes (coefficient -0.24, p=0.135) and cardiovascular diseases (coefficient -0.01, p=0.506). Inverted funnel-plot was relatively symmetrical. Egger's test indicates that the pooled analysis was not statistically significant for small-study effects (p=0.206).CONCLUSION:
Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension. PROSPERO REGISTRATION NUMBER CRD42020213491.
ACE2, Angiotensin Converting Enzyme 2; BMI, Body Mass Index; COVID-19; COVID-19, Coronavirus Disease 2019; CVD, Cardiovascular Diseases; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MOOSE, Meta-analysis of Observational Studies in Epidemiology; NOS, Newcastle Ottawa Scale; RR, Risk Ratio; TG, Triglycerides; WHO, World Health Organization; coronavirus; dyslipidemia; hyperlipidemia; prognosis; vLDL, very-low-density lipoprotein
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
J.jceh.2021.01.007
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