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Six-Month Psychophysical Evaluation of Olfactory Dysfunction in Patients with COVID-19.
Boscolo-Rizzo, Paolo; Menegaldo, Anna; Fabbris, Cristoforo; Spinato, Giacomo; Borsetto, Daniele; Vaira, Luigi Angelo; Calvanese, Leonardo; Pettorelli, Andrea; Sonego, Massimo; Frezza, Daniele; Bertolin, Andy; Cestaro, Walter; Rigoli, Roberto; D'Alessandro, Andrea; Tirelli, Giancarlo; Da Mosto, Maria Cristina; Menini, Anna; Polesel, Jerry; Hopkins, Claire.
  • Boscolo-Rizzo P; Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
  • Menegaldo A; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Fabbris C; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Spinato G; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Borsetto D; Department of ENT, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
  • Vaira LA; Unit of Maxillofacial Surgery, Sassari University Hospital, Sassari, Italy.
  • Calvanese L; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Pettorelli A; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Sonego M; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Frezza D; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Bertolin A; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Vittorio Veneto, Italy.
  • Cestaro W; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Montebelluna, Italy.
  • Rigoli R; Department of Clinical Pathology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • D'Alessandro A; Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
  • Tirelli G; Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
  • Da Mosto MC; Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Menini A; Neurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, Trieste, Italy.
  • Polesel J; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Hopkins C; Guy's and St Thomas' Hospitals, London, United Kingdom.
Chem Senses ; 462021 01 01.
Article in English | MEDLINE | ID: covidwho-1080838
Semantic information from SemMedBD (by NLM)
1. Evaluation TREATS COVID-19
Subject
Evaluation
Predicate
TREATS
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Evaluation TREATS Patients
Subject
Evaluation
Predicate
TREATS
Object
Patients
4. Diagnosis USES Laboratory Procedures
Subject
Diagnosis
Predicate
USES
Object
Laboratory Procedures
5. hypofunction PROCESS_OF Patients
Subject
hypofunction
Predicate
PROCESS_OF
Object
Patients
6. Sense of smell altered PROCESS_OF Patients
Subject
Sense of smell altered
Predicate
PROCESS_OF
Object
Patients
7. Evaluation TREATS COVID-19
Subject
Evaluation
Predicate
TREATS
Object
COVID-19
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
9. Evaluation TREATS Patients
Subject
Evaluation
Predicate
TREATS
Object
Patients
10. Diagnosis USES Laboratory Procedures
Subject
Diagnosis
Predicate
USES
Object
Laboratory Procedures
11. hypofunction PROCESS_OF Patients
Subject
hypofunction
Predicate
PROCESS_OF
Object
Patients
12. Sense of smell altered PROCESS_OF Patients
Subject
Sense of smell altered
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
This study prospectively assessed the 6-month prevalence of self-reported and psychophysically measured olfactory dysfunction in subjects with mild-to-moderate COVID-19. Self-reported smell or taste impairment was prospectively evaluated by SNOT-22 at diagnosis, 4-week, 8-week, and 6-month. At 6 months from the diagnosis, psychophysical evaluation of olfactory function was also performed using the 34-item culturally adapted University of Pennsylvania Smell Identification Test (CA-UPSIT). 145 completed both the 6-month subjective and psychophysical olfactory evaluation. According to CA-UPSIT, 87 subjects (60.0%) exhibited some smell dysfunction, with 10 patients being anosmic (6.9%) and seven being severely microsmic (4.8%). At the time CA-UPSIT was administered, a weak correlation was observed between the self-reported alteration of the sense of smell or taste and olfactory test scores (Spearman's r = -0.26). Among 112 patients who self-reported normal sense of smell at last follow-up, CA-UPSIT revealed normal smell in 46 (41.1%), mild microsmia in 46 (41.1%), moderate microsmia in 11 (9.8%), severe microsmia in 3 (2.3%), and anosmia in 6 (5.4%) patients; however, of those patients self-reporting normal smell but who were found to have hypofunction on testing, 62 out of 66 had a self-reported reduction in sense of smell or taste at an earlier time point. Despite most patients report a subjectively normal sense of smell, we observed a high percentage of persistent smell dysfunction at 6 months from the diagnosis of syndrome coronavirus 2 (SARS-CoV-2) infection, with 11.7% of patients being anosmic or severely microsmic. These data highlight a significant long-term rate of smell alteration in patients with previous SARS-COV-2 infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Olfaction Disorders Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Chemse

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Olfaction Disorders Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Chemse