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Clinical course of SARS-CoV-2 infection in patients with severe acquired brain injury and a disorder of consciousness: an observational study.
Caronni, Antonio; Liaci, Emanuele; Bianchi, Anna; Viganò, Alessandro; Marenco, Francesco; Comanducci, Angela; Cabrini, Daniela Maria; Meloni, Mario; Alberoni, Margherita; Farina, Elisabetta; Bianco, Mariangela; Galeri, Silvia; Devalle, Guya; Navarro, Jorge.
  • Caronni A; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Liaci E; Scuola di Specializzazione in Medicina Fisica e Riabilitativa, Università degli Studi di Bari "Aldo Moro", Bari, Italy.
  • Bianchi A; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Viganò A; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Marenco F; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Comanducci A; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Cabrini DM; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Meloni M; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Alberoni M; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Farina E; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Bianco M; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Galeri S; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Devalle G; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
  • Navarro J; IRCCS Fondazione Don Carlo Gnocchi Onlus, Milano, Italy.
Brain Inj ; 35(5): 520-529, 2021 04 16.
Article in English | MEDLINE | ID: covidwho-1080951
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
3. Severe brain damage PROCESS_OF Patients
Subject
Severe brain damage
Predicate
PROCESS_OF
Object
Patients
4. COVID-19 CAUSES Disease
Subject
COVID-19
Predicate
CAUSES
Object
Disease
5. Ground Glass Opacity PROCESS_OF Patients
Subject
Ground Glass Opacity
Predicate
PROCESS_OF
Object
Patients
6. Disease CAUSES Respiratory distress
Subject
Disease
Predicate
CAUSES
Object
Respiratory distress
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
8. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
9. Severe brain damage PROCESS_OF Patients
Subject
Severe brain damage
Predicate
PROCESS_OF
Object
Patients
10. COVID-19 CAUSES Disease
Subject
COVID-19
Predicate
CAUSES
Object
Disease
11. Ground Glass Opacity PROCESS_OF Patients
Subject
Ground Glass Opacity
Predicate
PROCESS_OF
Object
Patients
12. Disease CAUSES Respiratory distress
Subject
Disease
Predicate
CAUSES
Object
Respiratory distress
ABSTRACT

Purpose:

SARS-CoV-2 infection can cause the coronavirus disease (COVID), ranging from flu-like symptoms to interstitial pneumonia. Mortality is high in COVID pneumonia and it is the highest among the frailest. COVID could be particularly serious in patients with severe acquired brain injury (SABI), such as those with a disorder of consciousness. We here describe a cohort of patients with a disorder of consciousness exposed to SARS-CoV-2 early after their SABI.Materials and

methods:

The full cohort of 11 patients with SABI hospitalized in March 2020 in the IRCCS Fondazione Don Gnocchi rehabilitation (Milan, Italy) was recruited. Participants received SARS-CoV-2 testing and different clinical and laboratory data were collected.

Results:

Six patients contracted SARS-CoV-2 and four of them developed the COVID. Of these, one patient had ground-glass opacities on the chest CT scan, while the remaining three developed consolidations. No patient died and the overall respiratory involvement was mild, requiring in the worst cases low-flow oxygen.

Conclusions:

Here we report the clinical course of a cohort of patients with SABI exposed to SARS-CoV-2. The infection spread among patients and caused COVID in some of them. Unexpectedly, COVID was moderate, caused at most mild respiratory distress and did not result in fatalities.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Injuries / Consciousness Disorders / COVID-19 Topics: Long Covid Limits: Humans Country/Region as subject: Europa Language: English Journal: Brain Inj Journal subject: Brain Year: 2021 Document Type: Article Affiliation country: 02699052.2021.1887937

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Injuries / Consciousness Disorders / COVID-19 Topics: Long Covid Limits: Humans Country/Region as subject: Europa Language: English Journal: Brain Inj Journal subject: Brain Year: 2021 Document Type: Article Affiliation country: 02699052.2021.1887937