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Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.
Ebinger, Joseph E; Botwin, Gregory J; Albert, Christine M; Alotaibi, Mona; Arditi, Moshe; Berg, Anders H; Binek, Aleksandra; Botting, Patrick; Fert-Bober, Justyna; Figueiredo, Jane C; Grein, Jonathan D; Hasan, Wohaib; Henglin, Mir; Hussain, Shehnaz K; Jain, Mohit; Joung, Sandy; Karin, Michael; Kim, Elizabeth H; Li, Dalin; Liu, Yunxian; Luong, Eric; McGovern, Dermot P B; Merchant, Akil; Merin, Noah; Miles, Peggy B; Minissian, Margo; Nguyen, Trevor Trung; Raedschelders, Koen; Rashid, Mohamad A; Riera, Celine E; Riggs, Richard V; Sharma, Sonia; Sternbach, Sarah; Sun, Nancy; Tourtellotte, Warren G; Van Eyk, Jennifer E; Sobhani, Kimia; Braun, Jonathan G; Cheng, Susan.
  • Ebinger JE; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Botwin GJ; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Albert CM; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Alotaibi M; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Arditi M; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Berg AH; Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California, USA.
  • Binek A; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Botting P; Departments of Pediatrics, Division of Infectious Diseases and Immunology, and Infectious and Immunologic Diseases Research Center (IIDRC), Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Fert-Bober J; Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Figueiredo JC; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Grein JD; Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Hasan W; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Henglin M; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Hussain SK; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Jain M; Cedars-Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Joung S; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Karin M; Department of Epidemiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Kim EH; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Li D; Biobank & Translational Research Core Laboratory, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Liu Y; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Luong E; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • McGovern DPB; Department of Public Health Sciences and Comprehensive Cancer Center, University of California, Davis, Davis, California, USA.
  • Merchant A; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, California, USA.
  • Merin N; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Miles PB; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Minissian M; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California, USA.
  • Nguyen TT; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Raedschelders K; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Rashid MA; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Riera CE; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Riggs RV; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Sharma S; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Sternbach S; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Sun N; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Tourtellotte WG; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Van Eyk JE; Department of Internal Medicine, Division of Hematology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Sobhani K; Employee Health Services, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Braun JG; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Cheng S; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
BMJ Open ; 11(2): e043584, 2021 02 12.
Article in English | MEDLINE | ID: covidwho-1081430
ABSTRACT

OBJECTIVE:

We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers.

DESIGN:

Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires. SETTINGS A multisite healthcare delivery system located in Los Angeles County.

PARTICIPANTS:

A diverse and unselected population of adults (n=6062) employed in a multisite healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions. MAIN

OUTCOMES:

Using Bayesian and multivariate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody levels, including pre-existing demographic and clinical characteristics; potential COVID-19 illness-related exposures; and symptoms consistent with COVID-19 infection.

RESULTS:

We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom (OR 11.04, p<0.001) in addition to fever (OR 2.02, p=0.002) and myalgias (OR 1.65, p=0.035). After adjusting for potential confounders, seroprevalence was also associated with Hispanic ethnicity (OR 1.98, p=0.001) and African-American race (OR 2.02, p=0.027) as well as contact with a COVID-19-diagnosed individual in the household (OR 5.73, p<0.001) or clinical work setting (OR 1.76, p=0.002). Importantly, African-American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal COVID-19 diagnosis status, suggesting the contribution of unmeasured structural or societal factors. CONCLUSION AND RELEVANCE The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Seroepidemiologic Studies / Health Personnel / COVID-19 / Antibodies, Viral Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2020-043584

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Seroepidemiologic Studies / Health Personnel / COVID-19 / Antibodies, Viral Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2020-043584