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A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygiene.
Giarratana, Nadia; Rajan, Balan; Kamala, Kannan; Mendenhall, Michelle; Reiner, Giorgio.
  • Giarratana N; APR Applied Pharma Research S.A, 6828, Balerna, Switzerland. nadia.giarratana@apr.ch.
  • Rajan B; Eurofins Advinus Limited, Bengaluru, India.
  • Kamala K; Eurofins Advinus Limited, Bengaluru, India.
  • Mendenhall M; Institute for Antiviral Research, Utah State University, Logan, Utah, USA.
  • Reiner G; APR Applied Pharma Research S.A, 6828, Balerna, Switzerland.
Eur Arch Otorhinolaryngol ; 278(8): 3099-3103, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1081734
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus LOCATION_OF hypochlorous acid
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
hypochlorous acid
2. 2019 novel coronavirus LOCATION_OF hypochlorous acid
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
hypochlorous acid
ABSTRACT

INTRODUCTION:

To eliminate the COVID-19 pandemic, the transmission of the virus SARS-CoV-2 among the population needs to be blocked and/or at least reduced. Upper respiratory tract viral loads are highest in the early stages of the disease, and high loads are associated with higher mortality rates. This study aims to evaluate the virucidal efficacy of AOS2020, a novel sprayable Acid-Oxidizing solution containing pure and stable hypochlorous acid (HClO), on human coronavirus SARS-Cov-2 in vitro, and the tolerability profile on nasal and oral mucosa suggesting to be a potential solution for upper respiratory hygiene.

METHOD:

Virucidal assays and intranasal and oral irritation tests were undertaken in accordance with relevant national and international guidance and methods.

RESULTS:

In pre-clinical tests, the AOS2020, showed > 99.8% virucidal efficacy in < 1 min against SARS-Cov-2. The safety profile testing on both the nasal and oral mucosa indicates that AOS2020 is non-irritant.

CONCLUSION:

These initial results indicate that this product has the potential treatment to reduce viral load in the upper respiratory tract.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: SARS-CoV-2 / COVID-19 Subject: SARS-CoV-2 / COVID-19 Language: English Journal: Eur Arch Otorhinolaryngol Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: SARS-CoV-2 / COVID-19 Subject: SARS-CoV-2 / COVID-19 Language: English Journal: Eur Arch Otorhinolaryngol Year: 2021
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