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Clinical Outcomes and Immunologic Characteristics of Coronavirus Disease 2019 in People With Human Immunodeficiency Virus.
Ho, Hsi-En; Peluso, Michael J; Margus, Colton; Matias Lopes, Joao Pedro; He, Chen; Gaisa, Michael M; Osorio, Georgina; Aberg, Judith A; Mullen, Michael P.
  • Ho HE; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Peluso MJ; University of California, San Francisco, San Francisco, California, USA.
  • Margus C; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Matias Lopes JP; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • He C; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Gaisa MM; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Osorio G; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Aberg JA; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Mullen MP; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
J Infect Dis ; 223(3): 403-408, 2021 02 13.
Article in English | MEDLINE | ID: covidwho-1082007
ABSTRACT
We performed a retrospective study of coronavirus disease 2019 (COVID-19) in people with human immunodeficiency virus (PWH). PWH with COVID-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin 6, interleukin 8, and tumor necrosis factor α were commonly elevated. In all, 19 of 72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of COVID-19 despite antiretroviral therapy and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis