Halting SARS-CoV-2: lung organoids step up to the plate.
EMBO J
; 40(5): e107651, 2021 03 01.
Article
in English
| MEDLINE | ID: covidwho-1082516
ABSTRACT
Defining the pulmonary cell types infected by SARS-CoV-2 and finding ways to prevent subsequent tissue damage are key goals for controlling COVID-19. Recent work establishing a human lung organoid-derived air-liquid interface model permissive to SARS-CoV-2 infection identifies alveolar type II cells as the primary cell type infected, reports an infection-induced interferon response and demonstrates the effectiveness of interferon lambda 1 treatment in dampening lung infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Replication
/
Organoids
/
Alveolar Epithelial Cells
/
SARS-CoV-2
/
COVID-19
/
Models, Biological
Limits:
Humans
Language:
English
Journal:
EMBO J
Year:
2021
Document Type:
Article
Affiliation country:
Embj.2021107651
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