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Halting SARS-CoV-2: lung organoids step up to the plate.
Leibel, Sandra L; Sun, Xin.
  • Leibel SL; Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA.
  • Sun X; Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA.
EMBO J ; 40(5): e107651, 2021 03 01.
Article in English | MEDLINE | ID: covidwho-1082516
ABSTRACT
Defining the pulmonary cell types infected by SARS-CoV-2 and finding ways to prevent subsequent tissue damage are key goals for controlling COVID-19. Recent work establishing a human lung organoid-derived air-liquid interface model permissive to SARS-CoV-2 infection identifies alveolar type II cells as the primary cell type infected, reports an infection-induced interferon response and demonstrates the effectiveness of interferon lambda 1 treatment in dampening lung infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Organoids / Alveolar Epithelial Cells / SARS-CoV-2 / COVID-19 / Models, Biological Limits: Humans Language: English Journal: EMBO J Year: 2021 Document Type: Article Affiliation country: Embj.2021107651

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Organoids / Alveolar Epithelial Cells / SARS-CoV-2 / COVID-19 / Models, Biological Limits: Humans Language: English Journal: EMBO J Year: 2021 Document Type: Article Affiliation country: Embj.2021107651