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Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019.
Moccia, Francesco; Negri, Sharon; Faris, Pawan; Perna, Angelica; De Luca, Antonio; Soda, Teresa; Berra-Romani, Roberto; Guerra, Germano.
  • Moccia F; Laboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
  • Negri S; Laboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
  • Faris P; Laboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
  • Perna A; Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
  • De Luca A; Section of Human Anatomy, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Soda T; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Berra-Romani R; School of Medicine, Department of Biomedicine, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
  • Guerra G; Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
Front Physiol ; 12: 629119, 2021.
Article in English | MEDLINE | ID: covidwho-1082977
ABSTRACT
Emerging evidence hints in favor of a life-threatening link between severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and the cardiovascular system. SARS-CoV-2 may result in dramatic cardiovascular complications, whereas the severity of COronaVIrus Disease 2019 (COVID-19) and the incidence of fatalities tend to increase in patients with pre-existing cardiovascular complications. SARS-CoV-2 is internalized into the host cells by endocytosis and may then escape the endolysosomal system via endosomes. Two-pore channels drive endolysosomal trafficking through the release of endolysosomal Ca2+. Recent evidence suggested that the pharmacological inhibition of TPCs prevents Ebola virus and Middle East Respiratory Syndrome COronaVirus (MERS-CoV) entry into host cells. In this perspective, we briefly summarize the biophysical and pharmacological features of TPCs, illustrate their emerging role in the cardiovascular system, and finally present them as a reliable target to treat cardiovascular complications in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Front Physiol Year: 2021 Document Type: Article Affiliation country: Fphys.2021.629119

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Front Physiol Year: 2021 Document Type: Article Affiliation country: Fphys.2021.629119