Mucosal immune responses in COVID19 - a living review.
Oxf Open Immunol
; 2(1): iqab002, 2021.
Article
in English
| MEDLINE | ID: covidwho-2276001
ABSTRACT
COVID-19 was initially characterized as a disease primarily of the lungs, but it is becoming increasingly clear that the SARS-CoV2 virus is able to infect many organs and cause a broad pathological response. The primary infection site is likely to be a mucosal surface, mainly the lungs or the intestine, where epithelial cells can be infected with virus. Although it is clear that virus within the lungs can cause severe pathology, driven by an exaggerated immune response, infection within the intestine generally seems to cause minor or no symptoms. In this review, we compare the disease processes between the lungs and gastrointestinal tract, and what might drive these different responses. As the microbiome is a key part of mucosal barrier sites, we also consider the effect that microbial species may play on infection and the subsequent immune responses. Because of difficulties obtaining tissue samples, there are currently few studies focused on the local mucosal response rather than the systemic response, but understanding the local immune response will become increasingly important for understanding the mechanisms of disease in order to develop better treatments.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Reviews
Language:
English
Journal:
Oxf Open Immunol
Year:
2021
Document Type:
Article
Affiliation country:
Oxfimm
Similar
MEDLINE
...
LILACS
LIS