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Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain.
Rodilla, Enrique; López-Carmona, Maria Dolores; Cortes, Xavi; Cobos-Palacios, Lidia; Canales, Sergio; Sáez, Maria Carmen; Campos Escudero, Samara; Rubio-Rivas, Manuel; Díez Manglano, Jesus; Freire Castro, Santiago J; Vázquez Piqueras, Nuria; Mateo Sanchis, Elisabeth; Pesqueira Fontan, Paula Maria; Magallanes Gamboa, Jeffrey Oskar; González García, Andrés; Madrid Romero, Victor; Tamargo Chamorro, Lara; González Moraleja, Julio; Villanueva Martínez, Javier; González Noya, Amara; Suárez-Lombraña, Ana; Gracia Gutiérrez, Anyuli; López Reboiro, Manuel Lorenzo; Ramos Rincón, José Manuel; Gómez Huelgas, Ricardo.
  • Rodilla E; From the Internal Medicine Department, Hypertension and Vascular Risk Unit, Sagunto University Hospital, Sagunto (Valencia), Spain (E.R., X.C., S.C., M.C.S.).
  • López-Carmona MD; Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain (E.R., X.C., S.C., M.C.S.).
  • Cortes X; Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), Spain (M.D.L.-C., L.C.-P., R.G.H.).
  • Cobos-Palacios L; From the Internal Medicine Department, Hypertension and Vascular Risk Unit, Sagunto University Hospital, Sagunto (Valencia), Spain (E.R., X.C., S.C., M.C.S.).
  • Canales S; Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain (E.R., X.C., S.C., M.C.S.).
  • Sáez MC; Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), Spain (M.D.L.-C., L.C.-P., R.G.H.).
  • Campos Escudero S; From the Internal Medicine Department, Hypertension and Vascular Risk Unit, Sagunto University Hospital, Sagunto (Valencia), Spain (E.R., X.C., S.C., M.C.S.).
  • Rubio-Rivas M; Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain (E.R., X.C., S.C., M.C.S.).
  • Díez Manglano J; From the Internal Medicine Department, Hypertension and Vascular Risk Unit, Sagunto University Hospital, Sagunto (Valencia), Spain (E.R., X.C., S.C., M.C.S.).
  • Freire Castro SJ; Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain (E.R., X.C., S.C., M.C.S.).
  • Vázquez Piqueras N; Internal Medicine Department, 12 de Octubre University Hospital, Madrid, Spain (S.C.E.).
  • Mateo Sanchis E; Internal Medicine Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat (Barcelona), Spain (M.R.-R.).
  • Pesqueira Fontan PM; Internal Medicine Department, Royo Villanova Hospital, Zaragoza, Spain (J.D.M.).
  • Magallanes Gamboa JO; Internal Medicine Department, A Coruña University Hospital, Spain (S.J.F.C.).
  • González García A; Internal Medicine Department, Consorci Sanitari Integral, Moisès Broggi Hospital Sant Joan Despí (Barcelona), Spain (N.V.P.).
  • Madrid Romero V; Internal Medicine Department, Dr. Peset University Hospital, Valencia, Spain (E.M.S.).
  • Tamargo Chamorro L; Internal Medicine Department, Santiago Clinical Hospital, Santiago de Compostela (A Coruña), Spain (P.M.P.F.).
  • González Moraleja J; Internal Medicine Department, Nuestra Señora del Prado Hospital, Talavera de la Reina (Toledo), Spain (J.O.M.G.).
  • Villanueva Martínez J; Internal Medicine Department, Ramón y Cajal University Hospital, Madrid, Spain (A.G.G.).
  • González Noya A; Internal Medicine Department, Defensa General Hospital, Zaragoza, Spain (A.G.G.).
  • Suárez-Lombraña A; Internal Medicine Department, Zamora Hospital Complex, Spain (V.M.R.).
  • Gracia Gutiérrez A; Internal Medicine Department, Cabueñes Hospital, Gijón (Asturias), Spain (L.T.C.).
  • López Reboiro ML; Internal Medicine Department, Virgen de la Salud Hospital, Toledo, Spain (J.G.M.).
  • Ramos Rincón JM; Internal Medicine Department, Infanta Cristina University Hospital, Parla (Madrid), Spain (J.V.M.).
  • Gómez Huelgas R; Internal Medicine Department, Ourense University Hospital Complex, Ourense, Spain (A.G.N.).
Hypertension ; 77(3): 856-867, 2021 03 03.
Article in English | MEDLINE | ID: covidwho-1083643
ABSTRACT
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj] 1.27, P=0.0001; ORadj 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Pandemics / Vascular Stiffness / SARS-CoV-2 / COVID-19 / Hypertension Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Hypertension Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Pandemics / Vascular Stiffness / SARS-CoV-2 / COVID-19 / Hypertension Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Hypertension Year: 2021 Document Type: Article